Health
Scientists may have discovered drugs that improve human lifespan-News
Mifepristone is used by clinicians not only to end premature pregnancy but also to treat cancer and Cushing’s disease.
With major devastating discoveries, researchers may have found the beginning of a path to extending human life.
This study, published in the Journal of Gerontology: Biological Sciences, shows that the drug mifepristone can extend the lifespan of two very different species used in laboratory studies. It has potential implications for other species, including humans.
Mifepristone, also known as RU-486, is used by clinicians to end early pregnancies and to treat cancer and Cushing’s disease.
When I studied Drosophila (Drosophila), one of the most common laboratory models used in genetic research, I found that the drug mifepristone prolongs the life of female flies that mate.
“Our data show that in Drosophila, mifepristone directly or indirectly counteracts juvenile hormone signaling, but the precise target of mifepristone remains elusive.” Researchers at the University of Southern California, USA, said.
During mating, the female fruit fly receives a molecule called a sex peptide from the male, according to the researchers.
Previous studies have shown that sex peptides cause inflammation, shortening fly health and longevity.
Researchers say that giving mifepristone to mating Drosophila blocks the effects of sex peptides, reduces inflammation, keeps female flies healthier, and prolongs lifespan compared to unmedicated partners. I have found
The effects of the drug in Drosophila appear similar to those seen in women who take it.
“In situ, mifepristone reduces reproduction, alters the innate immune response, and prolongs life,” explained researcher John Tower.
“In humans, we know that mifepristone reduces reproduction and alters the innate immune response, so does that also prolong life?” he added.
To better understand how mifepristone functions to increase lifespan, the research team examined the genes, molecules, and metabolic processes that flies changed when the fly consumed the drug.
They found that a molecule called the juvenile hormone plays a central role. Juvenile hormones regulate fruit fly development throughout life, from eggs to larvae and adults.
Sex peptides appear to escalate the effects of juvenile hormones and shift the metabolism of mating flies to metabolic pathways that require more energy to maintain from a healthier process.
In addition, metabolic shifts promote deleterious inflammation, which appears to make flies more sensitive to toxic molecules produced by bacteria within their microbiome.
Mifepristone changes all that.
According to the researchers, when mating flies ate the drug, their metabolism stalled in a healthier route and lived longer than their mating sisters who did not take mifepristone.
“In particular, these metabolic pathways are conserved in humans and are associated with health and longevity,” the study authors write.
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