OKLAHOMA CITY — Scientists at the Oklahoma Medical Research Foundation say control of the sometimes deadly respiratory virus is one step closer to reality after the U.S. Food and Drug Administration approves the first preventive vaccine for the elderly. there is
The FDA this month approved a vaccine to protect people over the age of 60 from the respiratory syncytial virus, known as RSV. The vaccine is manufactured by British pharmaceutical company GlaxoSmithKline (GSK).
The U.S. Centers for Disease Control and Prevention follows FDA approval, which is expected to pave the way for an RSV vaccine for the elderly to become available in the United States this fall. Pharmaceutical companies Pfizer and Moderna are also in late-stage RSV vaccine development, including for pregnant women.
“This is a big step forward and it looks like further progress against this virus is on the horizon,” said OMRF physician and scientist Hal Scofield, M.D. Thanks to the global healthcare system, this first vaccine approval is welcome news. ”
RSV usually causes cold-like illness, but can cause lower respiratory tract infections such as bronchiolitis and pneumonia. Older people with chronic lung disease or heart disease, people with weakened immune systems, and young children are at highest risk for RSV complications. Schofield said the virus is “severely underdiagnosed” in adults.
The CDC estimates that RSV causes more than 60,000 hospitalizations and more than 6,000 deaths in adults over the age of 65 each year. GSK said in clinical trials involving 25,000 adults, its vaccine was more than 94% effective in preventing severe RSV.
GSK shots include technology dating back to the 1980s. It is called a recombinant subunit vaccine and is used for many vaccinations such as hepatitis B and whooping cough.
OMRF scientist Dr. Susan Kovats studies RSV. She is working to understand why the virus affects children so often, with more than 2 million doctor visits annually for children under the age of five, but older people are generally more affected. is. The research lays the groundwork for better treatments and could help design vaccines.
“There seems to be a correlation between viral load and age,” she says. “Preliminary data from our geriatric model indicate that the older we are, the more difficult it is to clear the virus.”
Scofield and Kovats said the approval of the first respiratory syncytial virus vaccine is good news, as long as it’s available to eligible people.
“Time will tell how widespread the vaccine will be,” Schofield said, adding, “But for older people who are most at risk of adverse outcomes from RSV, vaccination should come when that happens. I hope it will be an easy decision to take.”
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