Antiplatelet therapy is associated with less severe COVID-19 outcomes

Polish researchers today scientific report suggest to patient Are receiving antiplatelet therapy Before contracting the coronavirus, they were less likely to be admitted to the intensive care unit (ICU), less likely to develop shock, and have a lower three-month mortality rate. The study was conducted in 2020 and 2021, before vaccines were widely available in Poland.

The study compared the outcomes of hospitalized COVID-19 patients (274 patients) who were on antiplatelet therapy before infection with a control group who did not receive antiplatelet therapy.

Thrombosis, or blood clotting, has been implicated as a contributing factor to mortality from COVID-19, and the authors suggest that antiplatelet therapy is important because platelets play a key role in hemostasis, thrombosis, and inflammatory responses. We hypothesized that this may protect against severe thrombosis-related outcomes. Said.

In this study, 94% of patients took acetylsalicylic acid, including aspirin, during their coronavirus infection.

3-month mortality rate improved in antiplatelet group

In-hospital mortality was similar for patients in both groups, with 53 (19%) deaths in the antiplatelet therapy group and 64 (23%) deaths in the non-antiplatelet therapy group.

However, patients who were on antiplatelet therapy were less likely to go to the ICU (9% vs. 15%) and less likely to develop shock (9% vs. 15%). Three-month mortality was also lower in the antiplatelet therapy group (31% vs. 39%) (hazard ratio, 0.69; 95% confidence interval, 0.51 to 0.93).

More short- and long-term cardiovascular events were reported in the antiplatelet therapy group, which the authors suggest is likely due to pre-existing comorbidities.

Overall prognosis was better with AP [antiplatelet] group.

“Despite having more comorbidities and vascular events during hospitalization, the overall prognosis was better with AP.” [antiplatelet] group,” the authors write.

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