Health
Researchers develop new antibody that may treat several types of cancer
Researchers at Uppsala University and KTH Royal Institute of Technology have developed antibodies, a new form of precision medicine that could potentially treat several types of cancer. The researchers were able to combine three different functions of antibodies, which together powerfully amplify their effects. T cells About cancer tumors. The study was published in the journal Nature Communications.
Researchers have developed a unique type of antibody that targets and delivers the drug package through the antibody itself while simultaneously activating the immune system (a “3-in-1 design”). immunotherapy Treatment.
“For nearly 15 years, we have been researching how antibodies can be used to influence a key protein in the immune system (CD40) and precision medicine. Now, our new antibody method “We can show that precision medicine works in cancer,” explains Sarah Mangusbo, professor at Uppsala University's School of Pharmacy, who is lead author of the study along with KTH Royal Institute of Technology professor Johan Rockberg. .
This drug redirects the immune system to find and target specific mutations or genetic changes found only in cancer cells, known as neoantigens. This is achieved by the new antibody delivering its own tumor-specific substance directly to a specific type of immune cell and simultaneously stimulating this cell, giving it the ability to significantly enhance the T-cell response against the tumor. We are prepared.
The results show that this method works in several ways. In addition to activating the right types of immune cells in human blood samples, animal models have shown that treated mice survive longer, and higher doses can save mice from cancer. The method has been shown to be safer than previous cancer treatments. Treatments studied by researchers.
Developing customized precision medicines can be expensive and time-consuming.
The advantage of our drug is that it is easy to produce on a large scale, yet easily tailored to a patient's disease or specific tumor. The drug combines two parts: a targeted bispecific antibody that can be produced in advance in large quantities, and a custom peptide moiety that is synthetically produced on a small scale and rapidly for the type of cancer of interest. It consists of This should increase availability, both in terms of production costs and reducing the time it takes to tailor a peptide to a new tumor, reducing the time it takes for patients to go from diagnosis to treatment. ”
Johan Rockberg, Professor, KTH Royal Institute of Technology
The aim of this study was to establish a more flexible, faster and safer cancer treatment than currently available. This study has already shown that this method can be customized for each patient, thereby strengthening the immune system against cancer. The next step is to use a fully optimized manufacturing process to manufacture drug candidates for further safety studies and then begin human clinical trials.
sauce:
Reference magazines:
Mebratu, A. others. (2024). Bispecific CD40 agonist antibodies enable antibody-peptide complex formation and cancer-specific peptide delivery, improving T proliferation and antitumor immunity in mice. nature communications. doi.org/10.1038/s41467-024-53839-5.
|
Sources 2/ https://www.news-medical.net/news/20241111/Researchers-develop-new-antibody-with-potential-to-treat-several-types-of-cancer.aspx The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
