Health
Antineoplastic AR-12 may help treat COVID-19
Researchers in the United States have discovered that an antineoplastic drug called AR-12 inhibits the infection and replication of the Covid-19 virus into cells.
AR-12 has been widely studied as an anticancer and antiviral agent and has been shown to be effective against viruses such as deer, mumps, measles, rubella, chikungunya, drug-resistant HIV and influenza. ..
“AR-12 works in a unique way. Unlike other antiviral drugs, it inhibits the cellular chaperone, a protein needed to maintain the correct 3D shape of viral proteins,” in the United States.
“The shape of the virus is important to the ability of the virus to infect and replicate,” Dent added.
According to a study published in the journal Biochemical Pharmacology, one of the cellular chaperones inhibited by AR-12 is GRP78, which is essential for the replication of all viruses.
GRP78 acts as a type of cellular stress sensor and is required for the life cycle of all mammalian viruses.
Researcher Andrew Pokrepovic, who is leading the effort to translate these exciting findings into clinical trials, said:
“Since most Covid-19 drugs are given intravenously, this is a unique treatment option and will be potentially suitable for outpatient treatment as well as taking antibiotics,” Poklepovic added.
Poklepovic wants to begin patient enrollment in early 2021, but some milestones remain.
“To reach these important milestones and advance this research at the accelerated pace we need, we consulted Massey’s Side Cebuty, who has extensive drug discovery experience,” said Poklepovic. Says.
“We are working on submitting the information needed for US FDA approval, and we are in talks with a local pharmaceutical company to manufacture the investigational drug,” the study authors wrote.
“We hope that AR-12 will emerge as a treatment option for patients suffering from COVID-19, ultimately saving lives and contributing to a global pandemic solution,” they said.
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