Health
Acute kidney injury associated with increased mortality within 3 months of intracerebral hemorrhage-ScienceDaily
Patients suffering from intracerebral hemorrhage (ICH) are at increased risk of acute kidney injury (AKI) during hospitalization. AKI can lead to sudden renal failure, kidney damage, and even death. Researchers at the University of Missouri School of Medicine and MU Healthcare have determined which ICH patients are at greatest risk for this kidney disorder, so doctors can take precautions. They also investigated how the commonly used antihypertensive drug nicardipine contributes to AKI.
“For the past five years, clinicians have been concerned about AKI when they see patients with ICH, renal failure, and needing dialysis,” said Adnan I, Ph.D., Ph.D. in Clinical Neurology, MU School. .Qureshi, MD, said. Of medicine. “We need a more global physical approach to improve outcomes for ICH patients, rather than just focusing on the brain.”
Qureshi’s team found that within 4.5 hours of the onset of symptoms, systolic blood pressure was either intensive (110-139 mm Hg) or standard (140-179 mm Hg) drops above 180 1,000. We analyzed data from multicenter clinical trials in human ICH patients. The researchers identified AKI by taking a creatinine blood sample (indicating how well the kidneys are functioning) from each patient for 3 days. They found that 15% of all patients developed AKI, high doses of nicardipine were associated with an increased risk of AKI, and higher baseline serum creatinine levels increased the risk of AKI. In addition, patients with AKI were almost three times more likely to die within three months of diagnosis.
“Even the first set of laboratories seems to have predictions about who will develop AKI. This study provides values that doctors can use to determine who is actually at risk. I think it’s emphasized, “said Mr. Cresi. “We thought of an isolated brain disorder, but it’s not always the case.”
Qureshi says that the next step in AKI prevention after ICH is to identify high-risk patients using serum creatinine and other markers, take precautions to carefully manage intravenous fluids, and cause or worsen AKI. I think it’s about avoiding drugs that are likely to cause you.
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