Health
Studies have found that antibodies decline rapidly in the recovery of COVID-19 patients
According to one study, blood antibody levels in COVID-19 patients dropped rapidly in the weeks following the body’s removal of the new coronavirus, and symptoms subsided.
Due to the lack of approved and effective treatment for COVID-19, some hospitals treat patients with severe symptoms with plasma from recovering patients.
A new study published in the journal mBio concluded that convalescent plasma should be collected during a specific post-recovery time frame if it was shown to ultimately provide a clear benefit. ..
However, recovering patients cannot donate blood for at least 14 days after their symptoms have subsided, giving the body time to remove the viral particles.
“We don’t transfuse the virus, we just transfuse the antibody,” said Andres Finzi of the University of Montreal, Canada.
“But at the same time, our research shows that plasma’s ability to neutralize viral particles has diminished during their first few weeks,” Finzi said.
The SARS-CoV-2 spike protein plays an important role in helping the virus grab and invade the host cell.
Antibodies produced by the body’s immune system bind to parts of this protein, blocking the ability of this “key” to participate in the “lock” of the host’s cells, preventing viral particles from infecting the cell host. Prevent
Previous studies have suggested that antibodies to the SARS-CoV-2 spike protein peak 2-3 weeks after the onset of symptoms.
Findings from a previous cross-sectional study by Finge’s group of more than 100 patients found that the ability of plasma to neutralize the virus was significantly reduced between 3 and 6 weeks after the onset of symptoms. Suggested.
In a new longitudinal study, Finzi and his colleagues analyzed blood samples collected at monthly intervals from 31 individuals who recovered from COVID-19.
They measured the level of immunoglobulins acting on the coronavirus S protein and tested the ability of antibodies to neutralize the virus.
The researchers observed fluctuations in individual patient levels, but identified a consistent overall signal.
It was found that the levels of immunoglobulins G, A, and M targeting the binding site decreased 6 to 10 weeks after the onset of symptoms.
During the same period, the ability of antibodies to neutralize the virus also declined, according to researchers.
Antibody levels over time, not only to optimize the use of plasma during the convalescent period, but also to understand the effectiveness of the vaccine and whether previously infected people are at risk of reinfection. They added that it is important to understand how it changes.
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