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New research says antiparasitic drugs used since the 1980s may help stop coronaviruses

 


Australian researchers have published studies showing that drugs commonly used to treat parasitic infections can kill coronaviruses in the lab within 48 hours.

Researchers at Monash University in Melbourne, Australia, have found that the antiparasitic drug ivermectin can inhibit SARS-CoV-2 replication. The virus causes COVID-19. Investigation Published on journal Friday Antiviral research.

“Ivermectin is so widely used and considered a safe drug. We need to know right now if a human dose is effective. This is the next step,” said the research leader. Dr. Kylie Wagstaff said in a statement.

“We found that a single dose could essentially remove all viral RNA by 48 hours, and even at 24 hours it really was significantly reduced,” she added. .

The exact way in which the drug can kill the virus is not yet known, but Wagstaff said it probably did so by “weakening” the host cell’s ability to remove the drug.

Ivermectin has been widely used since the 1980s to treat infectious diseases caused by parasites such as head lice and scabies. The drug is also used to treat rosacea skin conditions.

Research has been done on cell culture in the lab, but it does not always lead to the effectiveness of people with the infection. Ivermectin was effective against a variety of viruses when studied in vitro. More research is needed to determine if the drug can be used to treat COVID-19.

Science lab
As the pandemic continues to spread around the world, scientists have focused on developing treatments for COVID-19.
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The virus is only known to exist for several months, but at least some of the teams involved in the new research already had experience before dealing with it.

“ As a virologist who was part of a team that first isolated and shared SARS-CoV-2 outside China in January 2020, we were excited about the prospect of ivermectin being used as a potential drug against COVID-19. Yes. ” Dr. Leonkari, the first author of the study and a virus identification specialist at the Victorian Infectious Diseases Reference Institute.

Newsweek The authors of the study were contacted for additional comments, but no response was received in time for publication.

Ivermectin’s status as a drug that has already been studied and approved for the treatment of other conditions offers crucial advantages over the development of new drugs. This is a long process that typically involves years of safety and efficacy research before reaching human patients.

Researchers have taken a similar approach when trying to develop treatments for COVID-19 by diverting many other drugs, including antimalarials Hydroxychloroquine Chloroquine, and the antiviral drugs lopinavir, ritonavir, and remdecivir, were developed to treat HIV and Ebola.

Although some preliminary studies have shown promise, these drugs have side effects that can be more harmful than side effects, making them a safe and effective treatment for COVID-19. It is not yet known whether it can be used.

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