Health
Cognitive impairment associated with severe COVID-19 risk
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Dementia and other cognitive deficits currently appear to be risk factors for developing severe COVID-19, according to a study from the University of Georgia. The findings highlight the need for special care for populations with these pre-existing conditions during a pandemic.
In a blinded trial, researchers analyzed data from about 1,000 illnesses and two illnesses. Specific gene Compare the health profile of COVID-19 patients with test-negative patients to find common ground among COVID-19 patients.
Studies published online in the journal Brain, behavior and immunityRelies on UK Biobank data, a long-term study of more than 500,000 participants investigating the respective contributions of genetic predisposition and environmental exposure to disease development.
Starting in March, UK Biobank began reporting participants’ COVID-19 status. The Franklin University of Arts and Sciences Department of Genetics team, led by Associate Professor Kaixiong Ye and his postdoc Jingqi Zhou, instantly linked COVID-19 status to electronic health data.
“We took a hypothetical approach, and the most statistically significant ones Cognitive impairment “Currently, we don’t know the mechanism behind these associations, we just know that they are more common in patients with COVID-19,” said Ye, senior author of the study.
Analysis Genetic factors Some people are at high risk for severe COVID-19, so the team focused on two genes. ACE2 and TPMPRSS2 are known to be important for the virus to invade human cells.
“In the TMPRSS2 gene, we found that certain genetic variations were more common in patients with COVID-19,” he said, and while the discovery was novel at the time, the team even on the genetic factors of the host. He added that he knows that more data exists. Three months ago.
The researchers also found that mutations in genes associated with SARS-CoV-2 infection may be associated with severe COVID-19 requiring hospitalization.
“And we’re starting to understand how these genetic variants make a difference,” he said, all over the world during the pandemic scientists are working on SARS CoV 2. We focused on the extraordinary pace of research. Follow up on your own early research, communicate with peers around the world, and contribute to your overall knowledge of the disease.
“When we’re working on one disease, the whole field is converging around the world at the same time, which really shows the power of science,” Ye said. “What my group is doing is really just Data analysis, Large-scale data mining, but from vaccine development to patient research, scientists disease From various aspects, and it is moving us very quickly in the fight against COVID-19. ”
Cognitive Disorders Related to Hospitalization of Jingqi Zhou et al, COVID-19: Results of an Observation Cohort Study, Brain, behavior, and immunity (2020). DOI: 10.1016 / j.bbi.2020.10.019
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University of Georgia
Quote: Cognitive impairment associated with severe COVID-19 risk (October 28, 2020) was posted on October 28, 2020 at https://medicalxpress.com/news/2020-10-cognitive-disorders-linked-severe Obtained from -covid-.html.
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