Health
Postmortem lungs in COVID-19 patients show significant damage
A Survey Of the 41 lungs that died of COVID-19 in Italy, extensive damage, persistent distortion of normal organ structure, scarring of respiratory tissue, and massive blood coagulation of arteries and veins were revealed. It was. People, so-called “long-distance carriers,” take months to recover from fatigue and shortness of breath.
The results were published yesterday The Lancet EBio Medicine journal. Researchers also examined tissues in the brain, heart, and kidneys, but these organs showed no signs of damage or viral replication.
The study, led by researchers at the University of Trieste and King’s College London, conducted a lung analysis from February to April and found that all 41 patients had extensive lung damage, 36 of 41 (88%). ), A large amount of abnormal blood coagulation was observed. Pulmonary arteries and veins.
Almost 90% of the lungs have shown that small cells are fused to large single cells with many nuclei. Fusion cells, or syncytium, are caused by the characteristic spike protein of COVID-19 that the virus uses to invade cells. This protein stimulates the fusion of infected cells with normal lung cells and can cause structural changes, inflammation, and abnormal blood clotting. These pathological changes were not seen in patients with pneumonia caused by pathogens other than coronavirus, the authors said.
Persistent abnormal cells
In all patients, the COVID-19 genome was found in respiratory cells, cells lining blood vessels, and syncytia. “The presence of abundant cytoplasmic RNA signals and spike protein expression in the lung 30-40 days after diagnosis in our study suggests ongoing replication and assumes a continued pathogenic role in viral infection. “I do,” the author wrote.
They said that the persistence of virus-infected cells and the unique molecular characteristics of the coronavirus spike protein set COVID-19 apart from other pneumonia. “The findings show that COVID-19 is more likely to be the result of these abnormal cells lasting longer in the lungs, not just a disease caused by the death of virus-infected cells.” King’s College Doctor of Medicine Mauro Jacka said at the University of London news release..
The average age of the patients was 77 for men and 84 for women. The underlying illness included high blood pressure (41-17) [41%]), Chronic heart disease (13/41) [32%]), Dementia (13/41 [32%]), Diabetes (12/41 [29%]), And cancer (12/41) [29%]).
The research team is currently assessing the effects of abnormal cells on blood clotting and inflammation and is looking for drugs that may block COVID-19 spike proteins and prevent cell fusion, the news release said. ..
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