Health
Antidepressants Can Help Prevent Severe COVID-19-Consumer Health News
Thursday, November 12, 2020 (HealthDay News)-The antidepressant fluvoxamine (best known under the brand name Luvox) may help prevent serious illness in patients with COVID-19 who have not yet been hospitalized. A new study reveals that there is sex.
The study included 152 patients infected with mild to moderate COVID-19. Of these, 80 took fluvoxamine and 72 took placebo for 15 days.
By the end of that time, all patients taking the drug had a serious illness, compared to six (8.3%) who took the placebo, according to researchers at the University of Washington School of Medicine in St. Louis. I didn’t see it progressing to. Louis.
“Patients who took fluvoxamine did not develop severe dyspnea or require hospitalization due to lung function problems,” said the first author, Dr. Eric Lenze of Psychiatry. I did.
“Most clinical trial treatments for COVID-19 are aimed at very ill patients, but finding a treatment that prevents them from becoming ill enough to require oxygenation or having to go to the hospital. It’s also important. Our study suggests that fluboxamine may help fill that niche. “
Fluvoxamine (widely used to treat depression, obsessive-compulsive disorder, and social anxiety disorder) is a type of drug called a selective serotonin reuptake inhibitor (SSRI). This class of drugs also includes drugs such as Prozac, Zoloft, and Celexa.
However, unlike other SSRIs, fluvoxamine has a strong interaction with a protein called the sigma 1 receptor, which helps regulate the body’s inflammatory response.
“There are several ways this drug may work to help patients with COVID-19, but we say it may interact with the sigma-1 receptor to reduce the production of inflammatory molecules. I think, “explained Dr. Angela Leiersen, senior author of the study. Professor of psychiatry.
“Past studies have shown that fluvoxamine can reduce inflammation in animal models of sepsis, which may be the same in our patients,” she said in a release.
Fluvoxamine may prevent the hyperactive immune response in COVID-19 patients by reducing inflammation. As a result, the risk of serious illness and death may be reduced, Reiersen said.
“Our goal is to help patients who are initially in good health to stay at home and prevent them from getting sick enough to be hospitalized,” said Dr. Caline Mattar, an assistant professor of medicine in the Department of Infectious Diseases. Said in the release. “What we’ve seen so far suggests that fluvoxamine may be an important tool for achieving that goal.”
Dr. Amesh Adalja is a senior scholar at the Johns Hopkins Center for Health Security in Baltimore. He wasn’t involved in the study, but the study “not only because of its positive results, but also because there is an urgent need for drugs to keep COVID patients away from the hospital. It’s also worth noting because of the way it was done. ” “
However, Mr Adalja emphasized the need for a larger trial “to see if promising findings are maintained.”
Researchers said they plan to begin such studies in the coming weeks, including patients from across the United States.
The preliminary survey was published online on November 12th. Journal of American Medical Association..
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For more information on COVID-19 Centers for Disease Control and Prevention..
Source: Senior scholar at the Johns Hopkins Health Security Center in Baltimore, Ameshua Darja, Maryland.Washington University in St. Louis, News Release, November 12, 2020
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
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