Health
Men and women develop aortic stenosis differently • Earth.com
New research from McGill University Aortic stenosis was found to not evolve equally in men and women.
Researchers were surprised to discover fluctuations in the mineral deposits that accumulated inside Aortic valve Among patients suffering from stenosis.
A narrowed aortic valve restricts blood flow and can lead to a heart attack or stroke. Aortic stenosis often progresses quietly over time, and symptoms only occur after the disease is already severe.
McGill team used the Canadian Light Source (CLS), a national research facility at the University of Saskatchewan, to examine heart valve damage in transplant recipients.
“To our surprise, we have shown that the types of minerals in heart valves vary by gender,” said research lead author Marta Sertti. “Unexpectedly, we found that females grew slower due to different mineral composition and shape.”
Using the CLS soft X-ray mischaracterized beamline, researchers analyzed mineral composition. They identified that types of mineral deposits were found almost exclusively in samples from female patients.
According to Cerruti, the findings show the importance of thinking about diversity in the context of research. This is a concept that has historically been a blind spot for the scientific community. For example, once it was standard to carry out experiments using only male mice.
“Our study is a perfect example of distorting the data by looking only at a particular population. Using a more diverse dataset will improve science.”
Professor Cerruti also notes that the study highlights the need for different diagnostic and therapeutic approaches in treating male or female aortic stenosis.
The research team returns to CLS to better understand the exact composition of mineral deposits found in women.
“Understanding what minerals are can definitely help in developing treatments,” said Sertti. “There could be an easier way to target these minerals and dissolve them for women.”
The study is published in a journal Acta Biomaterialia.
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Along Chrissy Sexton, Earth.com Staff writers
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