Health
Secondary infections, inflammation exacerbate Alzheimer’s disease, studies say
June 3 (UPI) – Studies show that Alzheimer’s disease and dementia can be exacerbated by secondary infections, even outside the brain Published on Thursday In the journal Alzheimer’s & Dementia.
Scientists have discovered that infection-induced brain inflammation can worsen the health of the brains of people suffering from dementia and Alzheimer’s disease, even elsewhere in the body.
This study, conducted at the Trinity Biomedical Sciences Institute in Dublin, examined neurons in mice with brains designed to mimic the effects of degenerative brain disease.
Mice that experienced secondary infections inflamed brain cells and accelerated disease progression, even outside the brain.
Researchers say the findings can have widespread implications: 10 million new cases of dementia are diagnosed each year, with 5% to 8% of the general population over the age of 60, according to the WHO. I’m affected.
“[Inflammation] It may contribute to the negative consequences of acute illness in older patients, such as episodes of delirium and the accelerated cognitive pathways seen in patients who experience delirium before or during dementia. ” Co-author, Associate Professor Colm Cunningham, Trinity’s School of Biochemistry and Immunology, said in a press release:
The findings could affect the way doctors approach patients with Alzheimer’s and dementia who are fighting infections, according to Cunningham.
Researchers said that part of the reason the diseased brain cells are dysfunctional is that they are already inflamed, and the infection exacerbates the inflammation, leading to confusion and abnormal behavior.
Studies have found that affected mice are victims of adverse reactions that resemble “delirium.”
The medical community has long known the degenerative effects of bad protein accumulation on the brains of patients with Alzheimer’s disease, but more attention has been paid to the effects of inflammation on the brain health of people with dementia. I will.
Previous studies have also shown that inflammation is involved in several forms of dementia. Last year’s phone The cycle of inflammation, brain cell death, and subsequent protein accumulation is a “vicious cycle.”
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