LC-MS method guarantees safer hydroxychloroquine dosage per individual

Side effects can be fatal even if hydroxychloroquine proves to be an effective treatment for COVID-19. In a recent study, researchers at Uppsala University found a workaround to adjust the hydroxychloroquine dose for each patient based on a whole blood test.

Originally developed to treat malaria, hydroxychloroquine has been shown to be effective in systemic lupus erythematosus and rheumatoid arthritis. In fact, it protects against flares of illness so well that it is currently recommended for all lupus patients. However, as seen by patients with malaria, the side effect of hydroxychloroquine, a problem of heart rhythm, is common and can be fatal.

After confirming that the levels of hydroxychloroquine differed significantly between individuals on the same dosing regimen, Uppsala researchers found that liquid chromatography-high-resolution mass spectrometry ( LC-HRMS) method was developed.

In this study, The researchers compared the levels of hydroxychloroquine in plasma, serum, and whole blood of 26 lupus patients. The variability between the three matrices was unexpectedly high, with hydroxychloroquine levels in whole blood approximately twice that in serum and plasma.

“One of the surprising results, and as a very important insight, the whole blood levels of patients prescribed the same dose can vary up to 15 times between individuals. This is how the drug is metabolized. There is a large individual difference,” said Kim Kurtima of the study authors Uppsala University and Uppsala University Hospital.

Therefore, after validation and application at both clinical and laboratory levels, researchers believe that whole blood is an excellent matrix and should be used for hydroxychloroquine analysis in monitoring patient therapeutic efficacy. I made a conclusion.

The LC-HRMS method has been used at Uppsala University Hospital since December 2019. The total chromatography time is only 4 minutes and the researchers report that it shows good linearity.

“Measurement of hydroxychloroquine in routine care helps clinicians motivate patients and improve treatment adherence and adjust doses accordingly, avoiding unnecessary addition of more toxic treatments. It also helps to monitor HCQ levels to minimize the risk of long-term side effects.” Research and treatment of arthritis..

The researchers warn that this method of analysis has proven effective in providing correct doses only to lupus patients, not to COVID-19 patients.

“We need to be very careful about making urgent conclusions about whether hydroxychloroquine is effective for COVID-19,” Kultima said.

That said, patients at Uppsala University Hospital would not want to be alert if hydroxychloroquine was indeed found to be effective against COVID-19. Researchers are now planning to work with doctors at infectious disease clinics and intensive care units at Uppsala University Hospital to enable rapid determination of hydroxychloroquine levels in the blood of COVID-19 patients. Confirming. It proves to be fruitful.

If the substance is found to be effective, be prepared to measure the drug level in the blood of COVID-19 patients.

..

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos