Health
JAK inhibitors show mortality benefits with severe COVID
The UK RECOVERY trial found that the addition of the Janus kinase (JAK) inhibitor baricitinib (Olmiant) to conventional treatment significantly reduced COVID mortality in hospitalized patients.
This drug, commonly used to treat rheumatoid arthritis, has a 13% lower 28-day mortality rate compared to regular care alone (age adjustment ratio). [RR] 0.87, 95% CI 0.77-0.98, P= 0.026).
Baricitinib was also associated with a high rate of survival and discharge within 28 days (80% vs. 78%, age-adjusted RR 1.10, 95% CI 1.04-1.15, P<0.01), and low risk of progressing to invasive ventilation or death in patients who were not initially ventilated (RR 0.90, 95% CI 0.89-0.99, P= 0.026).
In a press releaseIn all nine trials, including about 12,000 patients, the use of baricitinib or another JAK inhibitor was associated with a one-fifth reduction in deaths in patients admitted with COVID, RECOVERY researchers found. Pointed out (RR 0.80, 95% CI 0.71-0.89, P<0.01).
This is currently the fourth treatment to show mortality benefits in a practical RECOVERY trial. DexamethasoneIL-6 blocker Tocilizumab A combination of monoclonal antibodies of casilibimab and imdebimab.
Approved by FDA Baricitinib co-administered with remdesivir (Veklury), for critically ill COVID patients in November 2020.
In a statement, Dr. Martin Landray of Oxford Population Health said, “In people hospitalized for severe COVID-19, it is now sufficient that excessive immune response is the leading cause of lung damage. It has been established. “
“This opens up the possibility of using a combination of anti-inflammatory drugs to further reduce the risk of death for some of the most ill patients,” added Landray, who is also the Joint Chiefs of Staff for the RECOVERY trial. ..
this RECOVERY test phase Randomized 4,008 inpatients with COVID on regular care, 4,148 on regular care plus 4 mg tablets of baricitinib daily for 10 days or until discharge. Almost all (95%) patients received corticosteroids such as dexamethasone, less than a quarter received tocilizumab (actemra), and 20% received remdesivir. A little less than 70% received oxygen, while 27% received additional breathing assistance.
Overall, 12% of patients who received baricitinib died, compared to 14% of patients who received only conventional treatment. This was consistent regardless of whether the patient was taking corticosteroids, tocilizumab, or remdesivir.
They also stated that the short course of baricitinib did not increase the risk of thrombosis or infection.
These results are sent to the preprint server medRxiv It will soon be posted to a peer-reviewed journal for publication.
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