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Can Party Drug Ecstasy Help Treat PTSD? -Consumer Health News
Tuesday, March 22, 2022 (HealthDay News)-Party drug “ecstasy” could be the key to healing people from post-traumatic stress disorder (PTSD), new clinical trial results show is showing.
In a small study, patients with PTSD treated with a strong combination of psychedelic drugs MDMAAnd talk therapy was far more likely to put an end to their recurring nightmarish and overwhelming stressful episodes than those who received therapy alone, researchers said in San Diego this week. Reported at the annual meeting of the American Chemical Society.
Approximately two-thirds of those who received MDMA supportive care did not meet the diagnostic criteria for PTSD by the end of the session, whereas three who received talk therapy with placebo (inactive) medication. It was only one-third. The results showed.
Patients treated with MDMA also have less disability and depression and are less likely to abuse alcohol and drugs, said lead researcher Jennifer Mitchell. She is a professor of neurology and psychology at the University of California, San Francisco.
“In the end, the group receiving MDMA therapy was superior to the group receiving placebo plus therapy,” Mitchell said.
An estimated 11.8 million Americans PTSDResearchers said in a background note, and about half do not respond to standard treatments.
There was a growing interest in psychedelic compounds like MDMA, psilocybin and mescaline to help people with these and other mental states, Mitchell said. MDMA, which is illegal in the United States, is also known as Molly.
Not approved yet
The idea isn’t new, Mitchell said. Some psychiatrists dating back to the 1970s used MDMA to enhance psychotherapy, even though there were no formal clinical trials and the U.S. Food and Drug Administration did not approve its use for that purpose. Some people are doing it.
Mitchell and her colleagues have determined that it is time for a rigorous clinical trial of the potential usefulness of MDMA in treatment. They recruited 90 patients suffering from severe PTSD and randomly assigned them to receive either MDMA supportive care or placebo therapy.
Once a month, for 3 months, patients received large doses of MDMA intended to last for 8 hours.
Mitchell had two therapists staying with them during an eight-hour MDMA session.
During these daily monthly sessions, patients attended weekly treatment to organize what they learned during their MDMA trip.
Two months after the last session, 2 in 3 patients had no clinical diagnosis of PTSD because patients treated with MDMA-assisted therapy performed much better than the control group.
According to Mitchell, MDMA patients scored higher on tests measuring work, social and family life disorders. They also scored better on tests measuring the potential for alcohol and substance abuse.
Hormones that make you feel good at work
MDMA floods the brain Serotonin, a brain hormone that regulates moodMitchell said, much like antidepressants.
“Selective serotonin reuptake inhibitors, or SSRIs, also work by increasing the amount of serotonin present in these signaling regions of the brain,” Mitchell said. “MDMA does it even more powerfully, so when you administer MDMA to someone, not only can serotonin that has already been released stay there and signal longer, but it also triggers all of this additional serotonin release. increase.”
MDMA also facilitates release Another neurotransmitter, oxytocin It is usually considered a “hormone of love” or a “binding hormone,” Mitchell said.
Robert Motta, a professor of psychology at Hofstra University in Hempstead, New York, said this pleasing combination of hormones seems to help patients with PTSD overcome one of the most difficult hurdles in treatment. ..
“In order to treat PTSD, you need to meet a person again or confront their traumatic experience again, but if you do that, the person will run away unless you do it very carefully and slowly. They Was overwhelmed and stopped. “
“MDMA calms the amygdala that underlies many of these fear reactions and allows one to confront the traumatic experience without the incredible anxiety that causes them to escape,” he continued. ..
That’s why people with PTSD shouldn’t run out of ecstasy they buy on the street and start taking it, Motta said. They will miss the treatment that is at the heart of the treatment.
“If it’s so easy to do, anyone taking ecstasy at a party will cure their PTSD, and that’s not happening,” Motta said. “It’s not just MDMA, it’s MDMA Plus therapy that makes them better.”
Researchers are analyzing long-term data from the trial to see if MDMA therapy has sustained results, Mitchell said.They are also enrolling patients for a second trial to confirm their results
If all goes well, Mitchell expects PTSD’s MDMA-assisted therapy to be FDA-approved within a few years.
Motta does not know how popular the treatment of PTSD is, but considers it cost-effective compared to current treatments given how labor-intensive it is.
“Some of the more severe cases of PTSD in the Department of Veterans Affairs have seen little improvement over decades, but there is a dramatic improvement in MDMA,” Motta said. “The entire (MDMA) treatment procedure is quite long, but overall, it is not as expensive as what is currently being done to treat PTSD.”
The results of clinical trials prove this.Recent reports PLOS ONE, Researchers said MDMA therapy for PTSD could save about $ 133 million in the US healthcare system over 30 years compared to current therapies.
For more information
National Institute on Drug Abuse MDMA..
Source: Dr. Jennifer Mitchell, Professor of Neurology and Psychology, University of California, San Francisco. Dr. Robert Motta, Professor of Psychology at Hofstra University in Hempstead, NY. PLOS ONE, Online, February 25, 2022.American Chemical Society Annual Meeting, March 22, 2022
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