Health
Shreveport oncologists talk about breakthrough treatments for certain types of rectal cancer
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Shreveport, Louisiana Record (KSLA) Clinical trials Shows a potential breakthrough for treating some people with certain types of rectal cancer. In this study, all patients who received treatment saw the cancer remit within a few months.
“To date, this has been a very exciting development, as patients with this type of locally advanced rectal cancer usually require surgery, treatment, radiation therapy, and chemotherapy,” said Willis Knighton Health System’s medical oncologist. Dr. Lane R. Rosen said. ..
The study was conducted by the Memorial Sloan-Kettering Cancer Center, and all 14 participants participated in locally advanced rectal cancer with mismatch repair deficiencies.
“For mismatch repair patients, that means they do not have the ability to correct the mistakes that their normal DNA makes normally. Mismatch repair usually means those who have the ability to repair those mistakes. You get cancer faster than you can, “said Dr. Mindie Kavanaugh, a medical oncology scholar at LSU Health System.
Participants were treated with an immunotherapeutic drug called Dosterlimab every 3 weeks for 6 months. After completion and follow-up, the researchers said none of the patients showed signs of cancer.
“Dostarlimad is a monoclonal antibody that targets a receptor called PD1 that binds to and blocks PD1. The type of dostarlimad says that the body” this should not be here. ” Make it possible. It’s not a normal cell, so at that point we’ll try to destroy it and get rid of it, “Kavanaugh said.
Doctors say more research is needed to determine the effectiveness of the drug.
“Unknown yet, do these patients need to continue taking this drug forever? Is there a slow failure? But it is mismatch repair for patients with this particular genetic abnormality. It’s exciting because it means you have a deficiency, or Lynch syndrome or a similar type of illness. It may be possible to extend this to other disease sites. “
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