Health
Coinfection of bacteria associated with poor outcome of COVID-19 in chronic lymphocytic leukemia
Patients with chronic lymphocytic leukemia (CLL) infected with SARS-CoV-2 had a high case fatality rate and poor outcomes associated with bacterial coinfection, according to the results of a retrospective study presented at the EHA 2022 Hybrid Conference. .. ..
Previous studies have suggested that patients with CLL are particularly vulnerable to COVID-19, with reported case fatality rates of up to 40%. The purpose of this study was to characterize potential risk factors for adverse outcomes associated with COVID-19 in this population.
The retrospective study contains clinical records of 81 patients with CLL and SARS-CoV-2 infections treated for COVID-19 at three university centers in Serbia between March 2020 and December 2021. Was included.
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The median age of the cohort was 68 years, with 75% of patients being male. Comorbidity was common, with 72.3% of patients having at least 1. There were 13.6% of patients in remission, 35.8% receiving aggressive treatment, and 54.3% of untreated patients.
The majority of patients require oxygen supplementation, at 71.6%, including 43.2% of patients with severe COVID-19 and 23.5% considered critical. There were 30.9% of patients admitted to the intensive care unit, and 76% needed mechanical ventilation. The case fatality rate was 32.1%.
Case fatality was significantly associated with a Charlson comorbidity index greater than 4, at a rate of 38%, compared with 9.5% in patients with a low index (5%).P = .025).
Documented or highly suspected bacterial infections were present in 53.1% of patients and were treated with antibiotics and were significantly associated with an increased risk of death. Case fatality rate was 51.2% for patients with bacterial infections and 10.2% for patients without bacterial infections (10.2%).P <.001). This association remained important in multivariate analysis (as well).P = .012).
C-reactive protein (C-reactive protein (P <.001), D-dimer (P = .039), and lactate dehydrogenase (P = .002). Oxygen supplementation (P <.001) and admission to the intensive care unit (P <.001) was also associated with death. Age, gender, and history of CLL treatment were not associated with death.
The authors found that the poor outcomes associated with COVID-19 in patients in the cohort were “mainly due to the high rate of bacterial coinfection, reflecting vulnerability and susceptibility to both viral and bacterial infections. I will do it. “
Disclosure is not available for this presentation.
reference
Cvetkkovic Z, Markovic O, Markovic K, etc. Risk Factors for Unfavorable Outcomes in Inpatients with Chronic Lymphocytic Leukemia and COVID-19 – Experience from Three Serbian University Centers.. Announced at EHA2022. June 9-12, 2022. Summary P643.
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