Health
Yale University doctors at the heart of promoting new alopecia areata drugs are seeing proof with FDA approval
New Haven — 8 years, Dr. Brett King, Dermatologist at Yale University He is a very adventurous researcher or just “insane” in trying to treat alopecia areata alopecia patients with a drug originally known as a JAK inhibitor for rheumatoid arthritis. You may have thought.
The The FDA just approved the drug, Eli Lilly & Co. Manufactured by Baricitinib, it offers new treatment courses for hundreds of thousands and even millions of patients. Meanwhile, two similar JAK inhibitors, Pfizer and Concert, manufactured by other manufacturers are under development.
“It’s very important. It’s not a few people,” said King, an associate professor at Yale School of Medicine, who led two trials, including a one-year Phase 3 trial of Eli Lilly and Company. Human patient.
“This is hundreds of thousands of people in the United States, if not one or two million,” he said. “So getting the first FDA-approved drug in history will change this.”
So far, “nothing worked,” said King, who lives in Fairfield. The drug used earlier was “just … an immunosuppressant,” he said. Now, “the message between the hair follicles and the immune system can be literally interrupted,” he said.
In 2013, King was aware of an early study of mice linking a new class of drugs developed for rheumatoid arthritis, known as Janus kinase inhibitors or JAK inhibitors, to hair growth. A man in his early twenties from Killingworth came to King with psoriasis.
He also had alopecia areata.
King treated his patient Kyle Lohse with a Pfizer JAK inhibitor, which was approved for the treatment of arthritis a year ago. The results were dramatic — hair growth in a bald man with alopecia that was previously untreatable.
King has published his findings.
The way JAK inhibitors like baricitinib work is to block the “chemical message that goes back and forth between hair follicles and immune cells,” King said. “JAK inhibitors literally interrupt messages … and when those messages are interrupted, immune cells leave only hair follicles.”
The results of Phase 3 trials show that 39% of patients who received high doses and had at least 50% hair loss showed complete or near-complete hair recovery.
King presented his findings at the American Academy of Dermatology’s annual meeting in late March. The New England Journal of Medicine published its findings with King as the lead author.
Alopecia areata, a condition that causes dramatic and traumatic hair loss, is different from basic androgenetic alopecia, which is simply interpreted as “hair loss,” King said.
The public awareness exploded at the Academy Awards ceremony on March 27th. Actor Will Smith slapped host Chris Rock after Rock joked about the lack of hair of Smith’s wife, Jada Pinkett Smith... Pinkett Smith suffers from alopecia areata.
However, King’s work had received widespread attention for many years before.
“There were hundreds of patients who wanted to come to my clinic right away,” he said, after he first published details of his study in mid-June 2014.
One of those patients was Ida Carter of Southington, who has been a King patient for nearly two years now and said her experience with baricitinib was “amazing.”
Before receiving treatment, he had been suffering from this illness for about 12 years, saying, “I lost all my hair all over my body.” She said she was about 33 years old when her hair loss began.
“For me, this is very exciting,” Carter said. “Just having hope” is a big deal, she said. “There are many desperate people in this state.”
“I’ve achieved almost 100 percent regrowth,” Carter said, since she started treatment with baricitinib. “It’s pretty cool.”
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