Health
COVID Vax protects people of all weights from serious consequences
A large UK study found that the COVID-19 vaccine protects people from overweight and obese people from severe illness and death.
Dr. Carmen Piernas and colleagues at Oxford University report a significant reduction in the likelihood of COVID-related hospitalization two weeks after the second vaccination compared to each unvaccinated BMI group.
- Underweight: or 0.51 (95% CI 0.41-0.63)
- Normal weight: or 0.34 (95% CI 0.32-0.36)
- Overweight: or 0.32 (95% CI 0.30-0.34)
- Obesity: or 0.32 (95% CI 0.30-0.34)
Similarly, people vaccinated from all BMI groups have significantly increased protection against COVID-related deaths.
- Underweight: or 0.60 (95% CI 0.36-0.98)
- Normal weight: or 0.39 (95% CI 0.33-0.47)
- Overweight: or 0.30 (95% CI 0.25-0.35)
- Obesity: or 0.26 (95% CI 0.22-0.30)
However, comparing the vaccinated BMI groups with each other, there was a J-shape associated with severe COVID-19 after the second dose. This meant that there was an increased risk of underweight (BMI <18.5) and severe obesity (BMI> 40). , The group wrote Lancet Diabetes and Endocrinology..
After the third dose, very few cases were reported, but people in all BMI categories had significantly lower odds for severe COVID compared to unvaccinated individuals.
“Our findings provide further evidence that the COVID-19 vaccine saves lives for people of all sizes,” Piernas said in a statement. “Our results reassure us that the COVID-19 vaccine is as effective as people with a low BMI, and that vaccination significantly reduces the risk of serious illness when infected with COVID-19. Provided to obese people. “
“These data also highlight the need for targeted efforts to increase vaccine intake in people who currently have lower intakes than those with high BMI,” she added.
She points out that only 70% to 83% of underweight adults over the age of 40 were vaccinated twice or three times, compared to more than 80% of overweight or obese adults. did.
and Accompanying commentary, Annelies Wilder-Smith, MD, PhD, and Annika Frahsa, PhD, both at the University of Bern, Switzerland, state that this disparity with underweight people is less likely to be vaccinated. People who are overweight are at increased risk of severe COVID-19. This was supported by the UK’s risk-based strategy of deploying vaccines. “
“These findings are a shift to a more targeted and differentiated public health message to enhance vaccine intake for people who may feel that they are underweight and at low risk of severe COVID-19. Should encourage, “they suggested.
The findings are based on 9,171,524 adults in the QResearch database. Vaccination data was collected between December 2020 and November 2021. The average age of the population was 52 years and the average BMI was 26.7 years. A total of 19.2% were unvaccinated, 3.1% were vaccinated once, 52.6% were given twice, and 25.0% were given three times.
During this period, 566,461 people were COVID positive, 32,808 were hospitalized and 14,389 died.
This study used a consistent case-control design rather than a negative-test case-control design (the type of study design recommended by the World Health Organization). A better way.
Regarding the findings of underweight individuals, Wilder-Smith and Frahsa pointed out that this data is limited because it does not contain specific confounding factors that lead to underweight, such as cancer and weakness.
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Disclosure
This study was funded by the British Institute for Research and Technology Innovation and the Oxford Biomedical Research Center, National Institute of Health.
Piernas and co-authors reported their relationship with Novo Nordisk, ClinRisk, QResearch, Scottish Government COVID-19 Chief Medical Officer Advisory Group, NERVTAG, AstraZeneca, and the Ethnic Subgroup of the UK Emergency Science Advisory Group. ..
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Sources 2/ https://www.medpagetoday.com/infectiousdisease/covid19vaccine/99536 The mention sources can contact us to remove/changing this article |
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