Salt substitutes are consistently beneficial for BP, survival and CV events

August 10, 2022 Read in 2 minutes Source/Disclosure The issuer: Disclosure: The authors report no relevant financial disclosures. Add topic to email alert Get an email when new articles are posted Enter your email address to receive an email when new articles are posted . " data-action"subscribe"> Subscribe Your request could not be processed. Please try again later.If this issue persists, please contact us customerservice@slackinc.com. back to helio Salt substitutes consistently improved blood pressure and reduced the risk of mortality, cardiovascular mortality, and cardiovascular events, according to a meta-analysis published in . heart. "These findings are unlikely to reflect a play of chance and should be considered in clinical practice as strategies to reduce dietary sodium intake, increase dietary potassium intake, lower blood pressure, and lower blood pressure." and does not endorse the adoption of salt substitutes in public health policy. Prevent major cardiovascular events’” wrote the researcher. Data were obtained from Yin X et al. heart2022; doi:10.1136/heartjnl-2022-321332. The researchers performed a meta-analysis to determine the generalizability of the Salt Substitute and Stroke Study (SSaSS) results. As Helio previously reportedin the main results of the SSaSS, switching from regular salt to alternative salt reduced the risk of stroke, CV events, and death in rural Chinese adults with a history of stroke or at high risk of stroke. For the meta-analysis, researchers included 21 trials with 31,949 participants. Of the trials, 19 evaluated effects on blood pressure and five evaluated effects on clinical outcomes. According to the researchers, salt substitutes lowered systolic blood pressure by –4.61 mm Hg (95% CI, –6.07 to –3.14) and diastolic blood pressure by –1.61 mm Hg (95% CI, –2.42 to –0.79). I was. BP decline was affected by region, age, sex, history of hypertension, BMI, baseline 24-hour urinary sodium and baseline 24-hour urinary potassium (P. uniformity > .05), Shwejun Inn A PhD candidate in food policy at the George Institute for Global Health at the University of New South Wales in Sydney, writes: Systolic blood pressure decreased significantly by –1.53 mmHg (95% CI, -3.02 to –0.03; P. .045) and a significant reduction in diastolic blood pressure of -0.95 mm Hg (95% CI, -1.78 to -0.12; P. .025), according to researchers. Salt substitution decreased total mortality (RR 0.89; 95% CI, 0.85-0.94), CV mortality (RR 0.87; 95% CI, 0.81-0.94), and CV events (RR 0.89; 95% CI). ), 0.85-0.94), the researchers wrote, noting that 88% to 99% of the clinical outcome data came from the SSaSS. "Since blood pressure lowering is the mechanism by which salt substitutes provide cardiovascular protection, the observed consistent blood pressure lowering raises the generalizability of the cardiovascular protective effects observed in SSaSS beyond the SSaSS population outside of China." We are very adamant,” said Yin. wrote his colleague. reference: perspective back to top Matthew R. Alexander, MD, PhD This meta-analysis of 21 trials observed a consistent effect of salt replacement on blood pressure reduction across multiple geographic regions and baseline patient demographics. Salt substitutes reduced systolic blood pressure by an average of 4.6 mm Hg and diastolic blood pressure by 1.6 mm Hg. These are clinically significant blood pressure drops. Consistent with this, all-cause mortality, cardiovascular mortality, and cardiovascular events also decreased, largely due to the results of his recent large-scale SSaSS trial conducted in China. Overall, this meta-analysis suggests that salt substitution is likely to have significant benefits in reducing blood pressure across diverse communities. , people with chronic kidney disease or taking medications that may raise potassium were generally excluded from these trials, so its safety in these populations remains unknown. Most of the trials in this meta-analysis, especially the large trials, were conducted outside the United States. However, it is encouraging that the effects on blood pressure lowering were consistent across studies in Europe, Asia and the Americas, suggesting the generalizability of the benefits of salt replacement. It is recommended that you reduce your intake of foods high in salt, especially processed foods, and increase your intake of high-potassium foods such as fruits and vegetables. Therefore, although salt replacement can be a useful adjunct, there is currently a lack of evidence as to which salt replacements are best recommended for patients. It remains difficult to distinguish whether greater benefits come from salt reduction or potassium supplementation in salt replacement studies. Interestingly, however, in this meta-analysis the authors We found that every 10% decrease in sodium percentage was associated with a 1.53 mmHg decrease in systolic blood pressure. However, each 10% increase in potassium chloride in the salt substitute was not significantly associated with lower systolic blood pressure. This is worth further research. Matthew R. Alexander, MD, PhD Assistant Professor of Medicine Department of Clinical Pharmacology Vanderbilt University Medical Center Disclosure: Alexander does not report related financial disclosures. Add topic to email alert Get an email when new articles are posted Enter your email address to receive an email when new articles are posted . " data-action"subscribe"> Subscribe Your request could not be processed. Please try again later.If this issue persists, please contact us customerservice@slackinc.com. back to helio Rx Nutrition Resource Center Sources 1/ https://Google.com/ 2/ https://www.healio.com/news/cardiology/20220810/salt-substitutes-consistently-beneficial-for-bp-survival-cv-events The mention sources can contact us to remove/changing this article