Health
A recently evolved alarm molecule triggers inflammation — ScienceDaily
Scientists at Trinity College Dublin have made an important breakthrough in understanding how inflammation is regulated. I discovered that proteins actually do the opposite.
Their research has many potential implications, especially with respect to understanding and responding to autoimmune disease and inflammation.
Our immune system performs a very important function of protecting us from infection and damage, but when the immune response becomes overly aggressive, it can lead to harmful inflammation, which occurs in conditions such as rheumatoid arthritis and psoriasis. Inflammation is triggered when our bodies produce “alarm proteins” (interleukins). It enhances defenses against infection and damage by switching on various components of the immune system.
Understanding when and how such alarm proteins are produced and how the immune system is activated has led to major breakthroughs in the treatment of many immune diseases.
Now, scientists at the Smurfit Institute of Genetics at Trinity College Dublin, led by Seamus Martin, professor of genetics at Smurfit, have discovered that interleukin-37 has an unexpected function as an immune-stimulatory molecule. Did. As an “off switch” for the immune system.
Professor Martin said:
“Interleukins play an important role in regulating the immune system in response to bacterial and fungal infections. This has been a major impediment to understanding: much of what we know about the human immune system was first discovered in model organisms with a similar biological makeup to ours. I did.”
Prior to the new study, interleukin-37 was thought to have immunosuppressive functions, but exactly how it stopped inflammation was hotly debated. Scientists at Trinity report that interleukin-37 exhibits potent pro-inflammatory activity when activated in the right way.
Professor Martin added:
“This pro-inflammatory effect was highly unexpected. Our study shows that the protein binds to cutaneous interleukin receptors, which are known to play an important role in the progression of psoriasis.” There are four immune alarm molecules that signal through this particular interleukin receptor.
“It is a mystery why there are so many interleukins that bind to the same receptor, but we may speculate that this receptor has a very important sentinel function in our skin. Also, one alarm protein may not be enough: our skin is the major barrier between our body and the outside world that microbes break through to enter our body. It must and in many ways represents the first line of defense in our immune system.”
As such, interleukin-37 and other immune alarm proteins may have evolved to be different variations on the same theme. This allows the body to detect different types of infections by being activated by different enzymes for each infectious agent.
The study has just been published in a journal scientific immunology, This is a collaboration between several Trinity research groups led by Professor Martin’s team, which includes postdoctoral scientists Dr. Graeme Sullivan and Dr. Pavel Davidovich, and Professor Ed Lovell (Biochemistry and Immunology). Undergraduate) and Professor Pat Walsh (Clinical Medicine).
Story source:
material provided by Trinity College Dublin. Note: Content may be edited for style and length.
|
Sources 2/ https://www.sciencedaily.com/releases/2022/12/221216142625.htm The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: cgurgu@internetmarketingcompany.BizWebsite: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or collaboration@support.exbulletin.com
 |
 |
 |
