Health
Unique treatment can eradicate pancreatic tumors while stopping cancer progression
A unique treatment that combines radiation and immunotherapy can eradicate tumors in the pancreas while preventing the cancer from spreading, according to a new study by researchers at the University of Colorado Cancer Center.
A study published in the journal today cancer celloffers new hope for people with this often fatal disease.
This is the first time we’ve seen pancreatic tumor eradication suggest that cancer cells have a memory.Ultimately, this could change the way doctors treat patients. pancreatic cancer patient in the near future. “
Sana Karam, MD, PhD, first author, member of the CU Cancer Center at the University of Colorado Anschutz Medical Campus
They hope to conduct clinical trials using this treatment.
This study using animal models focuses on pancreatic ductal adenocarcinoma, which accounts for 90% of pancreatic cancer cases. Karam and her colleagues found that radiation and new immunotherapies induced significant systemic memory immune responses, and that antitumor effects could achieve eradication even after being re-challenged.
They hope the findings will improve survival in diseases that have historically not responded to immunotherapy.
According to Callum, combining the two treatments will allow patients to focus on eradicating the “bad” T cells within the immune system.
“If the disease is metastatic, we need to recognize and attack cell types everywhere, from the pancreas to the liver to the blood.”This approach does exactly that in our study.
Researchers used a novel variant antibody complex (aPD1-IL2v) that allows tumor expansion.antigen Certain T cells. This alone had a significant effect on local and distant tumor growth. It was further enhanced with the addition of radiotherapy.
Similar immunotherapies are being studied in Europe for other cancers. However, this is the first time that it has focused on pancreatic cancer in combination with radiotherapy.
“After just one radiation treatment, we saw a significant immune response that could change the way pancreatic cancer patients are treated,” said Karam. “I’ve never been more hopeful about the potential to improve survival for this disease.”
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