Health
Air pollution may increase risk of dementia complicated by genetics
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3 years ago, international studies Commissioned by the journal Lancet, it listed 12 modifiable factors that increase the risk of dementia. This includes three new factors: excessive alcohol, head injuries, and air pollution.
Writing the May 2, 2023 issue Alzheimer’s Journal, a team of researchers led by scientists at the University of California, San Diego, found that the last of these new factors—exposure to air pollution such as car exhaust and power plant exhaust—has a measurably greater risk. It explains in more detail how it is related to Dementia that progresses over time.
Lead author William S. Clement, Ph.D., professor of psychiatry and co-director of the Center for Aging Behavioral Genetics at the University of California, San Diego School of Medicine, and colleagues participated in the ongoing Vietnam-era twin study. We examined baseline cognitive assessments of approximately 1,100 men aged. Mean age at baseline he was 56 years and follow-up he was 12 years.
They also measured exposure to specific substances in the air (PM2.5) and nitrogen dioxide (NO2) produced when burning fossil fuels, as well as episodic memory, executive function, verbal fluency, and brain processing. Velocity and APOE genotype.
APOE is a gene that provides instructions to make proteins that are essential for the transport of cholesterol and other fats in the bloodstream. identified as a factor gene.
Researchers found that participants in their 40s and 50s with high levels of PM2.5 and NO2 exposure had cognitive decline in verbal fluency between the ages of 56 and 68. . Those with higher PM2.5 levels have worse outcomes in executive function, and those with higher NO2 exposure have shown worse outcomes, including episodic memory.
Executive functioning refers to the higher-level cognitive skills used to plan, control, and coordinate mental actions and actions. Episodic memory is the ability to recall and relive specific past events.
“The 2020 Lancet report concludes that modifying 12 risk factors, including education and middle-aged depression, could reduce the incidence of dementia by as much as 40%.” Aging Behavioral Genetics Director of Academic Center.
“The report places ambient air pollution as a higher risk for Alzheimer’s disease and related dementia than diabetes, physical activity, hypertension, alcohol consumption and obesity. Our findings suggest that It underscores the importance of identifying possible risk factors as early in life as possible, and the process by which air pollution influences the risk of subsequent cognitive decline is more complex than previous research suggests. We emphasize starting early.”
Co-authors are: Daniel E. Gustavson, University of Colorado Boulder. Jeremy A. Elman, Christine Fennema-Notestine, Donald J. Hagler, Jr., Xin M. Tu, Tsung-Chin Wu, Nathan Whitsell all, University of California, San Diego. Aaron Baraff, Puget Sound Health Care, Virginia, Seattle. Jaden DeAnda, University of California, San Diego, San Diego State University. Asad Beck and Joel D. Kaufman, University of Washington. Caleb E. Finch and Jiu-Chiuan Chen (University of Southern California). and Michael J. Lyons, Boston University.
Funding for this study was partially provided by the National Institute on Aging at the National Institutes of Health (Grants PO1 AG055367 and R01S AG050595, AG022381, AG076838, AG037985 and AG064955).
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