Immunity of COVID-19 rapidly declines, creating vaccination challenges

LONDON (Reuters)-New evidence that the body’s immune defenses against COVID-19 may be short-lived could help vaccine developers come up with shots that could fully protect people in the future wave of infection. It’s getting more difficult, scientists said Tuesday.

Preliminary studies in China, Germany, the UK, and others have shown that patients infected with the new coronavirus develop protective antibodies as part of their immune system’s defenses, but these appear to last only for a few months.

“Most people make antibodies (antibodies), but they can often be quickly debilitated, suggesting that they have little immunity,” said Daniel Altman, professor of immunology at Imperial College London. Told.

It poses a big problem for potential COVID-19 vaccine developers, and for public health authorities trying to deploy them to protect people from the future wave of pandemics.

“It means that overreliance on vaccines (to control pandemics) is unwise,” said Stephen Griffin, an associate professor of medicine at Leeds University.

To be really effective, the COVID-19 vaccines will have to “provide more potent and longer lasting protection… or they may need to be given on a regular basis. “He said.

“And they are not easy.”

Over 100 research teams and companies around the world are aiming to develop a vaccine against COVID-19, with at least 17 already participating in human trials to test efficacy.

Preclinical studies in pigs with the AstraZeneca COVID-19 vaccine, known as AZD1222, have shown that two doses produce a greater antibody response than one dose.

But so far, there are no data from human trials to show whether the immune response of protective antibodies is strong enough and lasts long.

Booster shot

Jeffrey Arnold, a visiting professor of microbiology at Oxford University in the UK and a former expert at Sanofi Pasteur, believes that one of the reasons for the lack of data is simply time. -Not long enough to show the longevity of the protection they offer.

He and other vaccination and immunology experts also said that debilitating immunity in the natural case of COVID-19 infection is not always the same as a vaccine-induced immune response:

“If possible, I want to improve nature,” he said in a telephone interview. “Of course, the vaccine is not directly infected with the virus, but it presents a surface protein delivered by another vector or created in the lab and injected into the arm, making it an ideal goal.” Makes the vaccine more effective than the natural one, making it more effective than the infection itself.”

Griffin said that if a viable vaccine was developed, the authorities would routinely give millions of people additional vaccines, or more than one of them to get the best possible protection. Said they should even consider combining the vaccines of.

However, in reality, that is a big challenge. “One dose of the vaccine in the whole world is one thing,” he said. “Giving them multiple doses is completely different.”

Our criteria:Thomson Reuters Trust Principles.

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