Lupus and arthritis patients are not at increased risk of severe COVID-19: Study-Health

Most adults with lupus or inflammatory arthritis are not at increased risk of hospitalization for COVID-19, two studies said Tuesday, in news that researchers published.

Lupus and the more common form of arthritis cause people’s immune systems to falsely attack their tissues, causing inflammation in the joints, skin, kidneys, and other parts of the body.

The majority of people affected by these diseases are women.

The new study was published in the journal Arthritis & Rheumatology and was led by researchers at the Grossman School of Medicine in New York University.

There was a note of concern-research found that patients with arthritis who took steroids rather than more targeted drugs known as biological drugs were at higher risk of requiring hospital treatment ..

However, the findings are generally positive news for patients with these conditions and report feeling uneasy that treatment makes them more susceptible to COVID-19.

In the first study, the researchers closely monitored the health status of 226 adults (mainly black, Hispanic, and female) who were treated for mild to severe lupus.

The group was examined and medical records checked during peak case loads in New York between April 14 and June 1.

Of the 83 people with confirmed or possibly COVID-19 cases of COVID, 24 were hospitalized and 4 died.

Researchers find that lupus patients taking immunosuppressive drugs such as mycophenolate mofetil (CellCept) and azathioprine (Imuran) are not at higher risk of hospitalization than those who are not. Did.

The second study monitored inflammatory arthritis (rheumatism, psoriasis, spondyloarthritis) in 103 Caucasian women treated between March 3 and May 4.

Unlike osteoarthritis, these are not primarily due to joint wear.

All cases were positive or likely to have COVID-19.

27 (26%) were hospitalized and 4 died (4%).

This was comparable to the rate found in all New Yorkers at 25%.

Dr. Ruth Fernandez-Ruiz, who co-authored one of the papers, told AFP that when the researchers started their study, the treatments patients received and the organ damage they caused, did not worsen the results. He said he was concerned.

“People with lupus or inflammatory arthritis have the same risk factors for COVID-19 as those with no disease,” she said.

Steroid notes

Patients with arthritis who were taking biological agents such as adalimumab (Humira) and etanercept (Enbrel) were not at high or low risk of hospitalization.

The same applies to hydroxychloroquine, which is another established treatment for immune disorders.

The fact that hydroxychloroquine has been independently studied as a coronavirus treatment does not increase or decrease the risk of hospitalization for COVID-19, further demonstrating that it does not work for this purpose.

Worryingly, patients with arthritis taking a mild dose of the steroid glucocorticoid were more than 10 times more likely to be hospitalized than those not taking the drug.

Steroids work by suppressing a broader immune system, but biologics are more selective and target specific proteins associated with inflammation.

Not all patients on steroids can switch to other medications.

The researchers, however, cautioned that the small sample size of the study may overestimate the risk.

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