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COVID-19 and obesity (Body mass index [BMI] > 30 kg / m2New data investigating how infectious patients with both COVID-19 and obesity are contagious, suggesting that the viral load is high and the virus persists longer in such individuals.
Dr Dr Dicker of Hasharon Hospital in Petachikva, Israel, briefly presented the preliminary results of his work at this year’s opening plenary of the European and International Conference on Virtual Obesity (ECOICO) 2020.
Dicker explained that obese patients were more contagious than non-obese patients, indicating that they had a BMI above 30 kg/m.2 Negative 5 days behind COVID-19 status with BMI less than 25 kg/m2, Is considered a healthy weight.
“We also know that obese patients have more viral load,” said Dicker, an obesity specialist.
“The genetic swabs show that high levels of ACE2 in adipose tissue increase the ability of the virus to enter cells,” he explains, pointing out that the study is novel and unpublished. Did. He has a contracted obese patient influenza It shows a similar pattern with higher viral load and longer duration of infection.
An ongoing large multicenter study to study obesity and COVID-19
In his study, BMI <25 kg/m2 And COVID-19 took about 14 days to fully recover, a person with a BMI of 25-30 kg/m2 People who take about 17 days and have a BMI above 30 kg/m2 It took about 19 to 20 days.
Dicker believes that higher levels of BMI and glucose in intubated patients are most likely to worsen morbidity. One possible explanation is that at baseline, patients with obesity have comorbidities and may further increase morbidity and mortality with the severe cytokine-storm typical of COVID-19. There is a factor.
In the case of COVID-19, many trials have associated obesity with worse outcomes. Data on the results of the Lille University Hospital in France, Reported Along Medscape Medical News In April, and Publish later In the journal obesity.. In these trials, the severity of COVID-19 was associated with an increase in the BMI category and was highest in patients with BMI ≥35 kg/m2 (Morbid obesity). Researchers also need to be invasive Mechanical ventilation Related to severe obesity, age, sex, diabetes, and High blood pressure..
Data show that as of March and April 2020, admissions to the Intensive Care Unit (ICU) began to increase sharply throughout France and elsewhere in Europe. François Patou, MD of Medicine at the University of Lille briefly mentioned these findings at the opening plenary session of ECOICO 2020, but his presentation was limited due to technical difficulties.
Other New York City data similarly featured Medscape Medical News The story also suggested that obesity may be a risk factor for ICU hospitalization in patients with COVID-19, especially those younger than 60 years. Obese patients were twice as likely to be hospitalized for COVID-19 and significantly more likely to have an ICU.
Further analysis by French doctors, including Pateau Published in July To of Lancet diabetes and endocrinologyCOVID-19 ICU patients were more likely to be 35% more obese than the severe COVID-19 patients in the French general population, among patients analyzed at the Lyon University Hospital (P = .0034).
Pattou is currently leading a large, international, multi-center study investigating how BMI and obesity are associated with an increased risk of COVID-19 mechanical ventilation. The study is using clinical rather than administrative data to investigate the association between BMI and the outcome of pneumonia in COVID-19 critically ill patients, Pattou said.
The study has recruited more than 1,400 patients from 21 centers in Europe, the United States, and Israel to date, based on clinical health data (not a controlled database).
Patto said Medscape Medical News“We hope this study will help us better understand the nature (both linear and non-linear) of the association between BMI and the severity of COVID-19 pneumonia, and require intermittent forced ventilation. I am, And mortality. I would also like to clarify the effect of gender, age, and metabolic covariates on that association. “
In an ECOICO 2020 press release, “It was unclear how many months after the COVID-19 pandemic this virus poses to people living with obesity. Using BMI To the point where almost all intensive care COVID-19 patients eventually reach the ventilator.”
Pattou and Dicker have not reported any relevant financial relationships.
ECOICO 2020. Announced on September 1, 2020. Opening plenary
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