Health
Antibodies attack the body in some COVID cases
October 30, 2020-For some people with severe COVID-19, the immune system can attack itself rather than the virus. New research It is published on the preprint server MedRxiv. This study has not yet been peer reviewed.
In these patients, as with other autoimmune diseases such as lupus and rheumatoid arthritis, the body creates “autoantibodies” that target human cells instead of the virus.
If doctors can detect these autoantibodies, they may be able to treat patients with drugs that already exist for autoimmune diseases. To New York Times.. Treatment is not a “cure”, but it can reduce the severity of symptoms.
Matthew Woodruff, the lead author and immunologist at Emory University in Atlanta, told the newspaper, “Some of these more aggressive drugs could more aggressively attack the right patients and expect better results. “.
Woodruff et al. Investigated 52 patients in Atlanta with severe or severe COVID-19 and no history of autoimmune disease. They found autoantibodies in about half of their patients, and over 70% of the top 50% of the most severe cases had autoantibodies.
Some of the autoantibodies are associated with blood clotting and blood flow problems and may be related to the clotting problems seen in this year’s COVID-19 patients. Ann Marshak Rothstein, an immunologist and lupus expert at the University of Massachusetts Worcester, told the newspaper that autoantibodies have no cure and can cause long-lasting problems if long-lasting. Told.
“It never really cures lupus. There is flare, it gets better, there is flare again,” she said. “And it may have something to do with autoantibody memory.”
The findings make sense, as other viral diseases also induce autoantibodies, scientists who weren’t involved in the study said. Certain immune cells, called B-immune cells, make antibodies against virus invaders, but the body can mistakenly make antibodies based on dead human cells killed by the virus.
“I’m not surprised, but it’s interesting to see it happen,” Akiko Iwasaki, an immunologist at Yale University, told the newspaper. “Even moderate to mild illnesses can elicit this type of antibody response.”
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