Health
Scientists reveal new drugs that direct stem cells to desired sites
Researchers at the Stanford Burnham Pre-Beads Medical Discovery Institute have recently developed a drug that can attract stem cells to damaged tissue and increase the effectiveness of treatment.
This is considered “scientific first”, not to mention major advances in the field of regenerative medicine. Such a discovery, Minutes of the National Academy of Sciences or PNAS What has been announced enhances current stem cell therapies developed to treat neurological disorders such as stroke, spinal cord injury, ALS or other amyotrophic lateral sclerosis, and other neurodegenerative diseases, and arthritis. And their use can be extended to new conditions such as heart disease.
In this study, administration of therapeutic cells or red blood cells and the drug SDV1a to neurodegenerated mice resulted in the disappearance of toxic or green cells. This corresponded to delayed onset of symptoms and longevity.
(Photo: Stem cell research by Getty Images)
This dateless handout, published by the Stem Cell Research Institute in 2005, shows neurons (red) and astrocytes (green) that can be made from neural stem cells.
Results suggestive of drug efficacy
The results of the study suggested that SDV1a could be used to increase the effectiveness of stem cell therapy. According to Evan Snyder, MD, PhD Stanford Burnham Prebeads Stem Cell and Regenerative Medicine Center “The ability to tell stem cells where to go in the body or to a particular area of a particular organ is the” holy grail “of regenerative medicine,” said the professor and director.
Snyder, the lead author of the study, added that it is now possible to direct stem cells to areas of interest and focus on their therapeutic effects.
Almost ten and a half years ago, a senior author, along with his team, discovered that stem cells were attracted to the infection. This is a biological “fire alert” that indicates that damage has occurred.
Nevertheless, the inflammatory environment can be dangerous to the body and inflammation cannot be used as a healing complaint. Therefore, researchers are looking for mechanisms to help move stem cells or “houses” to desired areas of the body.
Tools to help with disabilities
According to reports on this new discovery, such mechanisms or tools are in a state where preliminary inflammatory indicators such as chronic spinal cord injury and stroke disappear over time, and the role of inflammation is not clearly understood. It will be a big cause. One is heart disease.
Fortunately, after decades of investing in stem cell science, scientists are now making “amazing advances.” California Institute for Regenerative Medicine or CIRM President and CEO Maria Milan, MD, understands how such cells work and how they can be attached to help restore illness or injury. He said he was.
CIRM has partially funded this new study. Milan also said Snyder’s group identified drugs that could increase “the ability of neural stem cells to return to the site of injury and initiate repair.”
He also explained the president and CEO. Candidate drugs may help to quickly track the development of stem cell therapies, especially for conditions such as Alzheimer’s disease and spinal cord injury.
Maximized good bit
In the study, researchers were able to modify an inflammatory molecule called CXCL12 previously discovered by Snyder’s group to direct healing stem cells to areas that needed repair to develop SDV1a.
Thus, the new drug works by improving stem cell binding and minimizing signs of inflammation, and can be injected anywhere to attract stem cells to specific sites without causing inflammation.
Snyder explained that such inflammation can be dangerous, they modified CXL12 by “getting rid of dangerous beats and maximizing a good bit.”
Now he added, they have drugs that attract stem cells to the area of the disease, but they do not cause or exacerbate unwanted infections.
“Now we have drugs that attract stem cells to the area of the disease, but they do not cause or exacerbate unwanted inflammation.”
In addition, scientists transplanted SDV1a and human neural stem cells into the mouse brain to show that new drugs can improve the effectiveness of stem cell therapy. Sandhoff disease, Neurodegenerative diseases.
What is ahead
Scientists have already begun testing the ability of SDV1a to enhance stem cell therapy in a mouse model of Lugeric’s disease, also known as ALS, due to the progressive loss of motor neurons in the brain.
Snyder said he is optimistic that the mechanism of action of the new drug may help with a variety of neurodegenerative diseases and non-neurological conditions such as arthritis, heart disease, and even brain tumors.
Interestingly, he also explained that CXL12 and its receptors are said to be involved in a cytokine storm that illustrates severe illness. COVID-19 (new coronavirus infection) (# If there is no character limit, add parentheses when it first appearsSome of their understanding of how to control infection without selective control of other normal procedures may also be useful in that area.
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Check out more news and information about Stem cells At Science Times.
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