Connect with us


Primary progressive aphasia in Alzheimer’s disease does not predict amnesia




A small study found that patients with primary progressive aphasia (PPA) with Alzheimer’s disease had long-term memory retention.

Episodic memory was preserved in the first test and did not decline after 2.35 years. At that time, PPA symptoms had been present for 6.26 years, but language skills were significantly reduced, reported M. Marcel Meslam, a medical doctor at the Feinberg School of Medicine at Northwestern University in Chicago. , And co-author Neurology..

“The memory of people with primary progressive aphasia was initially unaffected, but it was unclear if they had maintained memory function for years,” Meslam said in a statement. “Most memory tests depended on the language skills these people lost or lost, making it difficult to determine.”

PPA is a neurodegenerative condition characterized by prominent language problems that worsen over time. Approximately 40% of patients with PPA present with atypical symptoms of Alzheimer’s disease and are often associated with a log-decreasing mutation of PPA.

The study included 17 PPA patients with Alzheimer’s disease compared to 14 with typical Alzheimer’s disease. PPA participants came from the northwest PPA research program There was also evidence of Alzheimer’s disease autopsy or biomarkers, and there were at least two consecutive visits with verbal and memory assessments. The pathology of Alzheimer’s disease was based on autopsy of 8 participants, 3 cerebrospinal fluid biomarkers, and 6 amyloid PET. Ten participants were men and 11 were logopenic PPA. The age at onset of symptoms ranged from 47 to 74 years, with an average of 59 years.

A typical group of Alzheimer’s disease included eight men and six women in the northwest. Alzheimer’s Disease Center He suffered from Alzheimer’s disease as the primary neuropathological diagnosis at autopsy. The average age of onset of symptoms was 66 years. In this group, both language memory and language function declined over time with the same severity.

Imaging performed only in the PPA group showed asymmetric left-sided medium-temporal atrophy. At necropsy, bilateral hippocampal neurofibrillary tangles were seen in both groups. Compared to the typical Alzheimer’s disease group, the PPA group had a lower incidence and lower frequency of mid-temporal TDP-43 pathology. APOE4 Genotype.

“Perhaps the most interesting finding is that memory preservation of the PPA-Alzheimer’s disease group is found in the medial temporal lobe structure of both groups, despite similarly widespread pathology,” said Seyed Ahmad of the University of California, Irvine. Sajjadi, MD, PhD said. , And co-author Ancillary editorial.. “Therefore, the medial temporal lobe structure of patients with PPA-Alzheimer’s disease can be considered resilient and intolerant to Alzheimer’s disease.”

The lack of right medial temporal lobe atrophy in the PPA group supports this idea. “This means the separation of neurodegeneration and pathology in patients with PPA-Alzheimer’s disease,” the editor writes.

“It seems reasonable to conclude that neurodegeneration correlates with the clinical manifestations of these patients, rather than just the presence of a medical condition, coupled with the broader cortical atrophy of the left hemisphere in the PPA group.” They added. “This is an important concept in the era of developing targeted therapies for people with no or minimal cognitive impairment.”

The limits of the study include the relatively small sample size. Autopsy was not available in all PPA cases. In addition, episodic memory was evaluated in different tests in the two groups.

  • Judy George Covering MedPage Today’s neurology and neuroscience news, brain aging, Alzheimer’s disease, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s disease, ALS, concussion, CTE, sleep, I’m writing about pain and so on. To follow


Neither the author nor the editor of the study reported disclosure.


What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos

Pictures Credit


to request, modification Contact us at Here or [email protected]