Health
Biomarkers associated with severe types of disease
Colored scanning electron micrographs of apoptotic cells (green) strongly infected with SARS-COV-2 virus particles (yellow) isolated from patient samples. Image taken at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Credit: NIH / NIAID
Recent studies have shown that the immune response plays a central role in the severity of COVID-19. Therefore, understanding the immune response that is generated as the disease progresses is key to determining which patients are at greatest risk of developing serious complications and dying as a result.
In a study published on February 26 Clinical Research JournalScientists and clinicians, led by Dr. Catherine Larochel, a neuroscientist at the University of Montreal (a researcher at the University of Montreal Hospital Research Center), found that a series of immune changes are particularly associated with SARS-CoV-2 infection. I showed that. Virus.
The research team also found that the changes were associated with the severity of COVID-19. disease, Evolution over 30 days, and death within 60 days.These biomarkers Potential therapeutic targetsAccording to La Rochel, the lead author of the study.
She told us about her discovery.
Your approach is quite unique. How could you identify the patients at greatest risk of poor prognosis based on the immunoprofiling performed?
Above all, this is the result of the great collaboration of dozens of people involved in this study and the research and clinical research at CHUM who participated in the Quebec COVID-19 (BQC19) biobank.
On the basis of Blood testInventory an immune cell population present in 50 patients with SARS-CoV-2 and compare it to a population of 22 and 49 healthy controls of the same sex and age hospitalized for other acute illnesses. I was able to.
This immune profiling was able to identify a subset of “dysregulation”. Immune cells Unique to patients affected by SARS-CoV-2. Most notably, some of these immune changes were associated with ventilation needs and mortality in these same patients.
These markers, which are unique to SARS-CoV-2, can help identify patients at greatest risk and may suggest new ways to develop therapeutic targets.
In addition, confirm that it was observed in other studies. For example, immune system disorders such as neutrophilia and lymphopenia are associated with the severity of the disease in inpatients, but are not unique to SARS-CoV-2.
From a clinical point of view, this can explain why common anti-inflammatory treatments such as steroids appear to work with COVID-19 and other acute illnesses.
How do you see the results being used directly in clinical practice? Is it technically feasible?
Using very small amounts of blood (less than 1 milliliter) to develop these immune profiles made these assays easy to move to clinical practice.
Our approach used techniques commonly used in hospital laboratories. Surface antibodies are used to “stain” cells that express specific markers, such as flow cytometry (cell characterization and counting). Clinical backgroundThis helps track patient progression over time and ultimately identify high-risk patients who require closer monitoring.
What kind of treatment range do you envision for your research activities?
We hope that our research will lead to the development of biomarkers that will help stratify patients based on their risk of developing severe forms of the disease. This will enable us to identify new therapeutic targets and better select patients who may benefit from specific available therapeutic approaches.
Rose-Marie Rébillard et al. Identification of SARS-CoV-2 specific immune changes in patients with acute disease, Clinical Research Journal (2021). DOI: 10.1172 / JCI145853
Provided by
University of Montreal
Quote: COVID-19: Biomarkers associated with severe disease (March 5, 2021) can be found at https://medicalxpress.com/news/2021-03-covid-biomarkers-linked-severe-disease.html Acquired on March 5, 2021
This document is subject to copyright. No part may be reproduced without written permission, except for fair transactions for personal investigation or research purposes. The content is provided for informational purposes only.
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
Pictures Credit
to request, modification Contact us at Here or [email protected]
 |
 |
 |
