Health
Delaying the second dose of COVID-19 vaccine can reduce mortality-study
The first dose of the COVID-19 vaccine, but delaying the second dose to people under the age of 65, may reduce the number of people who die of the disease, but only if certain conditions are met. , Predictive modeling studies have shown.
As the coronavirus pandemic continues, there is debate about whether to widen the gap between doses to give as many people as possible some protection, or to stick to the intervals specified in clinical trials.
For example, Pfizer (PFE.N) Although there is no clinical evidence to support the UK’s decision to extend the gap between vaccine doses to 12 weeks, data from deployments in the UK show a 70% reduction in infections and a single dose. It shows about 80% protection against death from administration. read more
A U.S. study published in the BMJ British Medical Journal used a simulation model based on a “real-world” sample of 100,000 U.S. adults, performed a series of scenarios, and performed infections under a variety of conditions. Predicted possible interactions.
These include different levels of vaccine efficacy and immunization rates, and different assumptions about whether the vaccine prevents infection and serious symptoms, or only serious symptoms, including death. Was there.
Researchers led by Thomas C. Kingsley of the Mayo Clinic in Rochester, Minnesota said, “The results show that under certain conditions, delayed second vaccination results in reduced cumulative mortality, infections, and hospitalization. It suggests that it can be achieved. “
Certain conditions include vaccines with a single dose efficacy of at least 80% and daily immunization rates between 0.1% and 0.3% of the population-but they were met. If the delayed second dose strategy is from 26 to 47 deaths per 100,000 compared to the normal schedule.
The optimal schedule was not recommended in this study.
“Decision makers need to consider local immunization rates and weigh the benefits of increasing these rates by delaying the second vaccination against the risks associated with the remaining uncertainty of this strategy. There is, “the team said.
Separately, a study of two doses of injections from different manufacturers, led by the University of Oxford, found the first findings regarding the frequency of common post-vaccination symptoms such as arm pain, chills, and malaise. Was reported.
People who have been vaccinated with Pfizer and then vaccinated with AstraZeneca, or vice versa, may report milder or moderate symptoms such as headaches and chills than if they were vaccinated twice with the same type of vaccine. It turned out to be highly sexual.
Pfizer and AstraZeneca were the first vaccines available in the UK to be tested in a “mix and match” study. Later, shots by Novavax and Moderna were added to the study. read more
According to Matthew Snape, a professor at Oxford University, important data on the immune response generated by different combinations of mixed or regular dosing schedules will be reported in the coming months.
Our criteria: Thomson Reuters Trust Principles.
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