Health
Scientists discover why obese people are more likely to die of coronaviruses, and why they believe fat cells are the cause – the sun
Scientists say they have found out why obese people are more likely to die of coronaviruses.
Adipocytes produce large amounts of protein, which Covid-19 uses to infiltrate human cells, according to researchers in Germany and the United States.
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Experts have found that angiotensin-converting enzyme 2 (Ace2) is produced in adipocytes in obese or diabetic patients more than others.
They say that it is this Ace2 protein that coronavirus binds in the body of infected people.
As written on the paper published in The Obesity Team magazine, the team therefore said that fat “may serve as a reservoir for the virus.”
They argued that certain types of cells in the lung, including fat, may contribute to patients with pulmonary fibrosis, or to scarring of the lungs.
This “is likely to affect the clinical severity of Covid-19,” they said.
Targeted treatment
On this basis, they suggested that a particular type of drug called thiazolidinedione (TZD) used to treat diabetes could be diverted to fight Covid-19.
Philip Scherrer of the Southwestern Medical Center at the University of Texas at Dallas, said he did not know about trials of TZDs in patients with coronavirus, in collaboration with Ilyakr Glicov of Welcomet GmbH, Germany. It was
He said: “We hope that the use of TZDs will be enjoyed in the future. These are clinically established drugs that have long been used in diabetes clinics, [are] Was considered safe. “
Until then he suggested: “Obese individuals at the upper end of the spectrum should be extra cautioned not to expose themselves to multiple levels of high-risk categories.”
However, some experts suggest that TZDs may be useful, but there is no evidence to work at this stage.
Ian Hall, a professor of molecular medicine and director of the Nottingham Center for Biomedical Research at Nottingham University, Times“Because the virus invades through the respiratory tract, it is likely that Ace2 expression levels in the respiratory tract are most important in the early stages of infection.
“One of our challenges is that there are multiple drug proposals that could work in Covid-19 based on a reliable hypothesis, but it takes time to properly evaluate all of them.
“Today, we are trying to achieve this through a coordinated national strategy led by major delivery infrastructures including Therapeutics Task Force and Biomedical Research Centers.”
Government investigation
Last night, Deputy Chief Scientific Advisor Dame Angela McLean said, Being obese was an “additional risk factor” for coronavirus patients Whether intensive care was required or eventually died during hospitalization.
She urged overweight people to overhaul their lifestyles to protect themselves from coronaviruses and other illnesses.
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At a Downing Street press conference on Tuesday, she said: “In fact, there is very detailed evidence gathered from patients in the hospital using Covid-19 from fairly beautiful studies, and these studies show that obesity is due to admission to the ICU, or indeed An additional risk factor for death.
“My understanding of how to lose weight is that dieting is not the way to do it.
“What you have to do is actually decide to completely change your lifestyle. You have to decide not only to diet, but to do something that lasts. not.
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“I understand that it’s really hard to do, but every situation-a pandemic or no pandemic-is better off not getting obese.”
Meanwhile, researchers at the University of Liverpool warned last week that obesity increased the risk of death from the virus by 37 percent.
The sun also revealed it Overweight British may have to work from home Under the draft lifting the British coronavirus blockade.
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