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Omicron subvariants share ominous properties with Delta

Omicron subvariants share ominous properties with Delta

 


Currently the predominant coronavirus variant in the United States is a member of the Omicron family, but scientists are better at spreading faster than Omicron’s predecessor, evading immunity, and can cause more serious illness. It states.

why? It is the dominant variant of the country in the middle of last year as it combines the characteristics of both Omicron and Delta.

A genetic feature reminiscent of the pandemic’s past, known as the delta mutation, seems to allow the virus to “escape existing immunity from vaccination and previous infections, especially if infected with Omicron waves.” Dr. Wesley Long, A Houston Methodist pathologist in Texas. That’s because the original Omicron strain that swept the world wasn’t mutated.

Omicron subvariant Landing In the United States — known as BA.2.12.1, 58% of US COVID-19 cases last week It’s not just — affected by delta mutations. Genetic changes are also present in Omicron’s relatives, who dominate together in South Africa. BA.4 and BA.5.. They have exactly the same mutations as Delta, but BA.2.12.1 has almost the same mutations.

This genetic change is bad news for those who have caught the original Omicron and thought it was unlikely to be re-infected soon. Most people aren’t sure which variant caused the disease, but the original Omicron caused a huge wave of cases from late last year to early this year.

For a long time, lab data suggest that previous infections with the original Omicron are less protective against reinfection with new variants, but the true risk of reinfection is with everyone. It is situation-specific.

But with a twist, people who were previously ill with Delta may have some additional armor to prevent new varieties.Reserve study According to researchers at Ohio State University, COVID-19 patients receiving intensive care for delta infections have better antibodies to neutralize new subvariants than those who caught the original strain of Omicron. Triggered.

“Omicron-infected antibodies do not appear to be well protected against subvariants compared to Delta,” he said. Dr. Chan LuluA research author who co-directs viruses and new pathogen programs in Ohio.

However, Liu said the level of protection provided by the Delta infection depends in part on when someone was ill. That is because the immune system weakens over time.

People who became ill with Delta should not consider themselves vulnerable to new subvariants, especially if they are not vaccinated, Long said. “Not everyone says it’s safe.”

One bright spot? Booster shots can provide strong protection against new variants, Liu said.

In general, vaccines and previous infections can protect people from the worst consequences of COVID-19. At this point, scientists say it’s too early to know if new subvariants will take root in the United States and significantly increase new cases, hospitalizations, and deaths.

Scientists are still trying to figure out how toxic these new variants are. Long said he had never seen anything to answer that question, but Liu said the new data indicate a more serious illness. Liu said the subvariants have properties that suggest that they spread more efficiently from cell to cell.

The virus “hides inside the cell and spreads through cell-to-cell contact,” Liu said. “It’s even scarier because the virus doesn’t come out because the antibody works.”

Dr. Eric TopolHead of the Scripps Research Translational Institute, the new subvariant certainly does not appear to be less toxic than previous versions of Omicron, and whether it is more toxic “will be revealed in the coming months.” Said.

In the meantime, scientists are hoping that the latest powerful varieties will spread rapidly as they are more contagious than their predecessors.

Home tests are difficult to track for all coronavirus infections in the United States, but data from Johns Hopkins University show cases averaging nearly 107,000 per day, up from about 87,000 two weeks ago. ..And the new hospitalization for COVID-19 patients Uptrend According to the Centers for Disease Control and Prevention, from around mid-April.

“I hope we don’t see the increase in hospitalizations we saw in the previous wave,” Long said. “But with COVID, whenever many people are infected, it’s just a number game. Some of them will get worse. Some of them need hospitalization. Unfortunately, some of them will die. “

Sources

1/ https://Google.com/

2/ https://www.latimes.com/science/story/2022-05-26/dominant-coronavirus-strain-contains-ghost-of-pandemic-past

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