Blocking mineralocorticoid receptors preserves renal function in diabetes

A study led by the University of Bristol in the UK showed that blocking the activation of mineralocorticoid receptors could help treat diabetic kidney disease, a condition that affects about 40% of people with diabetes. suggesting.

Kidney disease disproportionately affects people with diabetes, who are four times more likely than nondiabetics to require dialysis or a kidney transplant.

“Blocking the renin-angiotensin-aldosterone system with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker reduces the risk of albuminuria and end-stage renal disease. However, due to aldosterone escape, [these medications] We may not be able to reduce aldosterone-mediated stimulation of mineralocorticoid receptors,” Matthew Butler, consultant senior lecturer and MRC clinical scientist at the University of Bristol, and colleagues write in the journal. JCI Insight.

A common blood pressure drug called spironolactone, which blocks the activation of mineralocorticoid receptors, has recently been shown to be effective in treating this aspect of diabetic kidney disease by reducing the amount of protein entering the urine. However, it may have adverse effects such as high blood potassium levels.

Butler and colleagues in the UK, Italy, the Netherlands, and the US conducted the current study to more fully evaluate the mechanism of action of spironolactone in diabetic kidney disease. When the researchers examined kidney biopsy samples from patients with diabetic kidney disease treated with spironolactone, they found that spironolactone protects the kidneys by helping maintain the gel-like glycocalyx layer on the surface of the blood vessels in the organ. discovered to do The first part of the glomerular filtration barrier.

The researchers also studied rats with diabetic kidney disease and found increased albuminuria, glomerular albumin permeability, and glomerular matrix metalloproteinase levels with damage or loss of the glycocalyx layer.Butler and team found that blocking activation of mineralocorticoid receptors in rats alleviated these symptoms. Similar effects were also seen in human cell lines.

Data from individuals with diabetic kidney disease treated with mineralocorticoid receptor blockers showed reduced levels of matrix metalloproteinases and albuminuria.

“This study is very exciting for us as we have confirmed that blocking mineralocorticoid receptors using spironolactone, by acting on the glycocalyx, preserves kidney function,” said Butler in a press release. Did.

“Our next step will be to investigate repurposed drugs that target matrix metalloprotease enzymes to see if they are beneficial for kidney disease patients and avoid the troublesome side effects associated with mineralocorticoid receptor blockers. If the same level of protection is seen using these more specific drugs, patients will benefit greatly while avoiding the risks associated with high blood potassium levels.”

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos