Health
Fungal Infections Are Especially Dangerous For COVID-19 Patients, CDC Study Warns
Patients hospitalized with COVID-19 were more likely to die if they also had a fungal infection, according to a Centers for Disease Control and Prevention study.1
“Covid-19 is a significant risk factor for certain fungal infections, particularly those caused by invasive molds, which is probably due to the immune system dysregulation and immunodeficiency associated with COVID-19. Suppressive therapy is responsible,” the researchers wrote in their paper. emerging infectious disease.
During the pandemic, 48.5% of patients co-infected with COVID-19 and fungal infections had a mortality rate of 12.3%, compared with 12.3% of those with only fungal infections.
Co-infection with COVID-19 and fungal infections, regardless of the specific fungal agent involved, is associated with longer hospital stays, higher rates of intensive care visits, and use of invasive ventilators, according to research reports. increased morbidity and increased mortality. There is a call for increased surveillance of fungal diseases, especially during respiratory virus pandemics.
U.S. medical costs due to fungal infections totaled approximately $6.7 billion in 2018, with hospitalizations for fungal infections in the U.S. expected to increase by 8.5% annually from 2019 to 2021, reaching 7,000 in 2021. more people died. Risk factors for fungal infections include underlying medical conditions such as environmental exposure and immunodeficiency.
For this study, the researchers used a US hospital database containing anonymized data on patients admitted to more than 1,000 nongovernmental, community, and teaching hospitals. From 2020 to 2021, 39,423 patients were hospitalized with fungal infections, of which 5,288 (13.4%) also had COVID-19.
In covid-19 patients who also have fungal infections, the two most common fungal pathogens are: aspergillus, Involved in 27.8% of incidents, Candida, 21.5%. Other fungal pathogens that infect these patients are coccidioides, Pneumocystis, Histoplasma, Cryptococcus, Blast Mrs.Mucorales species, and other specific and non-specific fungi.
The median age of patients with dual infections was 63 years, while the median age of patients with only fungal infections was 61 years. Men are more likely to have fungal infections than women, accounting for 59.9% of patients with both COVID-19 and fungal infections and 57.5% of those with only COVID-19. rice field. Patients hospitalized with dual infections had the highest mortality rates for aspergillosis (57.6%), invasive candidiasis (55.4%), mucormycosis (44.7%), and unspecified mycoses (59.0%). )was.
Consistent with national mortality data, the authors noted that hospitalization of patients with dual infections “occurs disproportionately among nonwhite male patients in the western United States.”
“Observed racial or ethnic disparities in fungal infection-related hospitalization rates may be related to lack of access to health care, occupational exposures, and underlying conditions (e.g., diabetes) that may increase fungal infections. It may be related to long-standing inequalities in determinants of social health, such as the prevalence of HIV, and the risk of COVID-19 infection among certain minorities,” they continued.
The researchers emphasized the importance of “maintaining a high index of clinical suspicion of fungal infection in high-risk patients, including patients with new coronavirus infection,” and strengthened surveillance of mycosis. said to highlight the need for
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