Health
Here’s how the COVID-19 virus increases the risk of stroke in infected patients
Several studies have highlighted the association between COVID-19 and stroke. For example, a Rapid Review published in The Lancet Neurology suggests that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is more likely to cause thrombotic vascular events, including: stroke, Than other coronaviruses and seasonal infections. A new study, now led by the University of California, Los Angeles (UCLA), describes how the COVID-19 virus increases the risk of stroke in infected patients.
Researchers at UCLA used a 3D-printed silicon model of blood vessels in the brain to mimic the same forces that act on real blood vessels during COVID-19 infection.They discovered a condition called intracranial as the force generated by the blood pushing an abnormally narrowed artery. AtherosclerosisWhen it acts on the cells that line the arteries, it increases the production of angiotensin converting enzyme 2, or ACE2. ACE2 is a molecule used by coronavirus to invade cells on the surface of blood vessels.
Previous studies have shown that the coronavirus binds to endothelial cells in other organs, but it was unclear if it would also occur in the brain. Using the new model, researchers were able to discover that viral particles actually interact with the cells that line the blood vessels in the brain. This is mainly the area where the level of ACE2 is high.
This finding can explain the increased incidence of stroke COVID-19 infectionSaid Dr. Jason Hinman, an assistant professor of neurology at UCLA’s School of Medicine and lead author of the study.
Identify patients at high risk of stroke
In another finding, UCLA found that a specific set of immune response genes found in cerebrovascular cells was activated after coronavirus infection. These genes are found only in cerebrovascular cells and not in endothelial cells of other organs of the body.
This unique cerebral endothelial response to the virus may help identify patients at high risk of stroke, researchers said in a paper published in stroke (PDF).
To confirm the results of the current study, ULCA researchers will conduct a follow-up study using live coronavirus in a 3D-printed vascular model.
COVID-19 is an additional risk factor for stroke
COVID-19 increases the risk of stroke by 5.9% regardless of age, said Dr. NK Venkataramana, Founder Chairman and Chief Neurosurgeon of BGS Gleneagles Global Hospital in Bangalore. Talking to TheHealthSite, Venkataramana commented that COVID 19 is recognized as an additional risk factor for stroke and needs to be actively treated to reduce mortality and disability.
He explained that the tendency of the COVID-19 virus to the vascular endothelium due to the presence of the ACE 2 enzyme and the hypercoagulable state caused by COVID-19 are responsible for the stroke. Increased blood clotting Blood clot In the blood vessel. This interrupts the blood supply to the brain and can cause a stroke.
Benkata Ramana warned that the coronavirus can cause cerebral hemorrhage. It is a type of stroke that causes bleeding in or around the brain and is found in a small proportion of patients.
Therefore, he proposed early diagnosis and intensive care for both COVID-19 and stroke, along with correction of coagulation abnormalities.
Release date: December 20, 2020 14:12
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