Health
Covid-19 Outbreak: Mumbai Civil Society Launches Rendesibir Clinical Trials at Nair Hospital-Urban
Starting clinical trials of Remdesivir, an antiviral drug used to treat Ebola hemorrhagic fever, at Covid-19 at BYL Nair Hospital after testing Itolizumab, a drug used for psoriasis at the Burihan Mumbai Municipal Company (BMC) Has been decided.
Remdesivir is an antiviral drug developed by US pharmaceutical giant Gilead Sciences in 2014 to treat Ebola. It has since been used to treat Middle East respiratory syndrome and severe acute respiratory syndrome. Both of these are caused by other strains of coronavirus. It has been shown to effectively block the Sars-CoV-2 virus and promote recovery in patients with coronavirus. With cases set to exceed the 18,000 mark, BMC is keen to improve recovery rates.
“Clinical trials of rendecibir in other countries have shown successful treatment of patients with coronaviruses, which do not cure patients like Tamiflu, but reduced recovery time by 11-15 days, resulting in We can expedite discharge, ”said Suresh Kakani, BMC Vice Chairman (Health).
“It works by stopping the replication of the virus,” the World Health Organization (WHO) said in a statement.
Explaining how the drug works, says city-based epidemiologist Dr. Om Srivastava: “Sars-Cov-2 causes Covid-19, which has a single ribonucleic acid (RNA) segment that replicates when an enzyme is used to infect a cell—a polymerase, which binds with a new strand of RNA. RNA is made up of four bases, rendecivir is an analog that mimics one of these bases, adenine, so when the drug is injected into the body, the virus It grabs and inserts it into RNA, so it destroys RNA and stops it from producing more virus. “
To get the fastest scientific data for treating patients with Covid-19, WHO has announced a “solidarity trial”. The trial encourages thousands of patients around the world to try promising drugs and disclose the results.
The International Health Community maintains that of drugs in WHO solidarity trials, and rendecibir has the best potential. The drug shows that it can be used in high doses without causing toxicity.
The National Institute of Allergy and Infectious Diseases (NIAID) has successfully completed a study of rendecibir in 1,063 patients. Again, a study conducted by Dr Aruna Subramanian, a clinical professor of medicine and infectious diseases at Stanford University School of Medicine in California, showed that 50% of patients receiving 5 mg of drug improved in 10 days. However, Covid-19 patients in a study published under the International Scientific Journal of Lancet, “Rendecibir in Adults with Severe COVID-19: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study.” “
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