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People infected with tick-borne Lyme disease — precision vaccination

People infected with tick-borne Lyme disease — precision vaccination

 


(Precision vaccination)

Lyme disease continues to spread around the world, but there is little scientific consensus on how common this tick-borne disease is.

To close this knowledge gap, open access journals BMJ Global Health Data analysis pooled on June 13, 2022 revealed that more than 14% of the world’s population probably had or had antibodies to the Borrelia burgdolferisenstrat (Bb) infection in the blood. discovered.

The three regions with the highest reported seroprevalence were Central Europe (21%), East Asia (16%), and Western Europe (13.5%).

At the other end of the scale, the regions with the lowest reported seroprevalence were the Caribbean (2%), South Asia (3%), and Oceania (almost 5.5%).

A smaller pool analysis of the results of 58 different studies shows that elderly people (aged 50+), men, rural residences, and tick bites are all associated with an increased risk of Bb antibodies. I showed that I was there.

“Our results show that the prevalence of Bb from 2010 to 2021 was higher than that from 2001 to 2010,” the study author writes.

However, the authors of the study conclude that: “The reported estimated global Bb seroprevalence is relatively high …[Lyme disease] Although it is a widely distributed infectious disease, it has not received much attention around the world. “

“A more accurate picture of its global distribution and who is at greatest risk of infection” can inform the formulation of public health response policies, [Lyme disease] “Control program”, they suggest.

“There is no way to know exactly how many people have Lyme disease,” the US CDC said.

Recently released estimates based on insurance records suggest that approximately 476,000 Americans are diagnosed and treated for Lyme disease each year. Anyway, this figure shows that the healthcare system is overwhelmed and more effective precautions are needed.

The US FDA has not approved a Lyme disease prophylaxis vaccine, but one candidate is conducting a late-stage Phase 3 clinical trial.

Valneva SE vaccine candidate based in France VLA15 Is a multivalent recombinant protein vaccine that targets the outer surface protein A of borrelia and is intended to protect against most human pathogenic borrelia species.

Valneva and New York-based Pfizer announced a collaboration to develop and commercialize VLA15 in April 2020.

On February 4, 2022, Valneva and Pfizer announced a three-dose first-series vaccination schedule in a planned Phase 3 clinical trial in adults and children. It will begin in the third quarter of 2022, subject to regulatory approval.

Dr. Katrin U. Janssen, Senior Vice President and Head of Vaccine Research and Development at Pfizer, commented in a press release issued April 26, 2022: The footprints of the illness spread. “

“These positive pediatric data show significant progress in the ongoing development of VLA15 and can continue to work with Valneva, which may help protect both adults and children from Lyme disease. I’m glad. “

Note: Conflicts of interest in the research industry are not disclosed. Don Y, Zhou G, Cao W, etc. Global seroprevalence and sociodemographic characteristics of Borrelia burgdorferisensrat in the human population: Systematic review and meta-analysis BMJ Global Health 2022; 7: e007744.

Professor Fukai Bao; [email protected]..

Precision Vaccinations Publish fact-checked, research-based vaccine news curated for mobile readers.

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2/ https://www.precisionvaccinations.com/who-infected-tick-borne-lyme-disease

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