Health
India’s COVID-19 vaccine turns out to be effective and safe for infants — precision vaccination
Hyderabad-based Bharat Biotech International Limited today found that its all-virus inactivated COVID-19 vaccine Covaxin (BBV152) is safe, well tolerated and immunogenic in Phase II / III pediatric subjects. Announced that it turned out.
new study Of the 526 children funded by the company, it was published in the peer-reviewed journal TheLancetInfectiousDiseases on June 16, 2022.
Covaxin Is uniquely prescribed so that the same dose can be given to adults and children alike for the first dose and the booster dose, making it a “universal” COVID-19 vaccine.
Dr. Krishna Ella, Chairman and Managing Director of Bharat Biotech, commented in a press release issued June 17, 2022: Immunogenicity in children. “
“.. Covacin has proven to be a very safe vaccine based on data from more than 50 million doses given to children in India.”
The advantage of this study is the demonstration of acceptable tolerability and significant immunogenicity of BBV152 in children up to 2 years of age, supported by a safety profile similar to that of adults.
The inactivated COVID-19 vaccine has been shown to be well tolerated and immunogenic in Phase 1/2 trials in Chinese children aged 3 to 17 years.
The advantage of all virion vaccines such as BBV152 is the presence of multiple epitopes, as indicated by the prominent response of this study to S, RBD, and N proteins.
In addition, after booster immunization (third dose), BBV152 became a variant of concern containing adult omicrons, even though it induced only low or moderate neutralizing antibody titers compared to the mRNA vaccine. On the other hand, it showed enhanced in vitro neutralization.
Vikkurthi et al. Also showed that ex vivo T cells produced by BBV152 help B cell production of antibodies against the SARS-CoV-2 mutant of concern.
These findings are important because children are more susceptible to and can be infected with the SARS-CoV-2 virus, even though they have milder symptoms than adults.
As of April 2022, approximately 350 million covaxin doses have been distributed worldwide.
This vaccine is not licensed in the United States by the US FDA.
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Sources 2/ https://www.precisionvaccinations.com/2022/06/17/indias-covid-19-vaccine-found-effective-and-safe-toddlers The mention sources can contact us to remove/changing this article |
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