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Did you know that common food dyes can cause inflammatory bowel disease? Researchers reveal

Did you know that common food dyes can cause inflammatory bowel disease? Researchers reveal

 


According to Waliul Khan of McMaster University, IBD, Crohn’s disease, and ulcerative colitis can all be at risk from long-term consumption of the food dye allura red.

Studies using animal models of IBD show that prolonged exposure to Allura Red AC adversely affects gut health and promotes inflammation. This dye directly impairs intestinal barrier function and increases serotonin synthesis. Serotonin is a gut hormone/neurotransmitter that alters the composition of the gut microbiota and promotes the risk of colitis.

Allura Red, also known as FD&C Red 40 and Food Red 17, is a common ingredient in candies, sodas, dairy products, and some cereals, according to Khan. It is often drawn by children by putting out

Over the last few decades, the use of artificial food colors like Allura Red has increased significantly, but there hasn’t been much prior research into how these colors affect gut health. In Nature Communications, Khan and his team published their findings. The first author is Yun Han (Eric) Kwon, a recent Ph.D. student working in Khan’s lab.

“This study demonstrates significant detrimental effects of Allura Red on intestinal health and identifies intestinal serotonin as a key factor mediating these effects. and management,” said Khan, senior author of the study, professor in the Department of Pathology and Molecular Medicine, and principal investigator at the Farncombe Family Digestive Health Research Institute. .

“Our findings are surprising and alarming because this common synthetic food dye can cause IBD. “It’s an important advance in warning the public about the potential harm of the virus,” he said.

“The literature suggests that consumption of Allura Red may also affect behavioral problems in children, such as certain allergies, immune disorders, and attention deficit hyperactivity disorder.”

Khan said IBD is a severe, chronic inflammatory condition of the human gut that affects millions of people worldwide. Their exact causes are still not fully understood, but it is known that dysregulated immune responses, genetic factors, gut microbiota imbalances, and environmental factors can cause these conditions. Shown by research.

In recent years, great progress has been made in identifying susceptibility genes and understanding the role of the immune system and host microbiota in the pathogenesis of IBD. But similar progress in defining environmental risk factors has lagged, he said.

According to Khan, environmental factors for IBD include a typical Western diet, including lack of processed fat, lean and processed meat, sugar and fiber. Western diets and processed foods also contain large amounts of various additives and colorings, he added.

He said the study suggested an association between commonly used food dyes and IBD, and that food dyes and IBD need to be further investigated at the , epidemiological, and clinical levels. Added.

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