Health
Parkinson’s test detects disease before symptoms appear: What you need to know
A spinal fluid test may predict who is likely to develop Parkinson disease years before symptoms first appear. According to new research.
Parkinson’s disease is a degenerative syndrome in which brain circuits involved in movement, thinking and behavior are slowly lost. It is the most rapidly progressing neurodegenerative disease with approximately 90,000 people diagnosed each year. According to a 2022 study.
There is no blood test or laboratory test to diagnose Parkinson’s disease, said Michael Henderson, a neuroscientist at the Van Andel Institute, a biomedical nonprofit dedicated to researching Parkinson’s and other diseases. I’m here.
But experts say the spinal fluid test could be the first step toward a minimally invasive test that uses blood tests and nasal swabs to diagnose Parkinson’s disease.
Deborah W. Brooks, CEO of the Michael J. Fox Foundation, which sponsored the study, said:
latest:Parkinson’s disease is more common than you think. Toxins may contribute to the increased rate.
How is Parkinson’s disease diagnosed?
Although current treatments help reduce symptoms, there is no cure for Parkinson’s disease. This syndrome can cause tremors, stiffness, sluggishness, and falls, in addition to anxiety, depression, and sleep disturbances. Most patients are diagnosed at an average age of 60, according to experts.
The disorder is usually diagnosed by a neurologist after an evaluation of symptoms, possibly combined with a brain scan and the patient’s response to medication.
However, without criteria for movement disorders such as tremor, slowness of movement, stiffness, and postural instability, there is no way to know if someone has Parkinson’s disease.
“What the field has been looking for for a long time is a biomarker that essentially indicates that a patient had biologically developed Parkinson’s disease before they had symptoms,” he said. “What this research does is expand on what the field has been trying to do.”
The test, called the α-Synuclein Seed Amplification Assay, uses a patient’s spinal fluid to identify synuclein pathology, one of Parkinson’s disease’s two biological hallmarks, according to scientists at the Parkinson’s Disease Progression Markers Initiative. detect.
A study of over 1,000 participants enrolled between 2010 and 2019 included people with Parkinson’s disease, or those with genetic or clinical risk factors but no diagnosis, and control volunteers were included.
While the test won’t replace professional diagnosis, it could “shape how and when Parkinson’s disease is diagnosed,” said Rachel Dolhan, senior vice president of medical communications at the Michael J. Fox Foundation. says Dr.
Michael J. Fox:Knowing the early markers and symptoms can put an end to Parkinson’s disease
“New Biological Era”
The study’s findings may also have implications for drug development and clinical care, said principal investigator Kenneth Malek, Ph.D., president and senior scientist at the Institute for Neurodegenerative Diseases.
“Validation of this biomarker opens a new biological era in the study of Parkinson’s disease,” he said. “We are in a position to test new treatments in the right populations, to put the right treatments in the right patients at the right time, and to collectively initiate research into drugs that may prevent Parkinson’s disease. will be rapidly placed on
The test, called the SYNTap test by biotech company Amprion, is available for doctors to order for patients showing symptoms of Parkinson’s disease or related disorders. But Henderson said treatment options may need to catch up before doctors use it more in clinical practice.
“Unless there is a specific treatment for those patients, there is not necessarily a real purpose of improving the diagnosis,” he said. there is no”.
Celebrities diagnosed with Parkinson’s disease include actors Michael J. Fox Alan Alda, boxer and humanitarian Muhammad Ali, singer Linda Ronstadt, Neil Diamond.
In a statement about the research, Fox said, “There are many ways that I have been involved in the work of the Foundation, but first and foremost I arrived at this result as a Parkinson’s patient.”I am deeply moved by this breakthrough. We are endlessly grateful to the researchers, research participants, and funders who have brought us this far.”
“Together we are creating an inevitable cure for Parkinson’s disease.”
Digging deeper: Other health news
Contributors: Karen Weintraub, USA TODAY. Follow Adrianna Rodriguez on her Twitter: @AdriannaUSAT.
Health and patient safety coverage on USA TODAY is made possible in part by a grant from the Masimo Foundation for Ethics, Innovation and Competition in Healthcare. The Masimo Foundation does not provide editorial opinion.
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