Health
Pitavastatin calcium is associated with a 35% reduction in CVD risk in HIV-infected people
REPRIEVE Study — A large global trial investigating the effects of daily statins HIV Low to moderate risk of cardiovascular disease (CVD) – ahead of schedule with interim results suggesting that pharmacotherapy significantly reduces the risk of heart attack, stroke, and other serious cardiovascular events Canceled. Published by the National Institutes of Health (NIH).
In the REPRIEVE trial, HIV participants were randomized to receive 4 mg of the statin pitavastatin calcium daily or placebo. They were monitored for major adverse cardiovascular events and adverse reactions to pitavastatin, which is considered safe for use in combination with all prescribed antiretroviral therapy regimens.
Interim results showed that HIV-infected people taking pitavastatin calcium had a 35% reduction in the risk of serious adverse cardiovascular events compared to those taking placebo.
Furthermore, adverse drug events observed in this study were similar to those generally observed in the general population receiving statin therapy. The Data Security and Monitoring Board (DSMB) came to recommend early termination of the study for adequate efficacy, which the NIH accepted.
“REPRIEVE research reflects the evolution of HIV science, from approaches that primarily treat and control the virus, to finding ways to improve the overall health of people living with HIV. National Institute of Allergy and Infectious Diseases (NIAID): “These new data suggest that common cholesterol-lowering drugs can significantly improve cardiovascular outcomes in HIV patients.”
The REPRIEVE study started in 2015 and was conducted in 12 countries across Asia, Europe, North America, South America and Africa. The trial included her 7769 participants aged 40 to her 75, more than 30% of whom were female. All participants were receiving antiretroviral therapy and had a CD4+ cell count >100/mm3 of blood at enrollment. These individuals were also at low to moderate risk for her CVD conventionally and did not usually require statin treatment.
The study’s independent DSMB conducted periodic reviews of safety and efficacy data at planned intervals throughout the study. At its latest meeting, the DSMB concluded that the benefits of daily use of pitavastatin outweighed the risks and recommended early termination of the study with full data collection at all sites for final analysis. Recommended. Study participants have been informed of the findings and their health will continue to be monitored for several months. The results of the DSMB review will be published in the coming weeks.
“These latest findings represent the culmination of an unprecedented eight-year effort to generate evidence to help clinicians better support the unique cardiovascular health needs of people living with HIV. “We are doing it,” said Gary H. Gibbons, MD, Director of National Heart, Lung. and the Blood Institute (NHLBI). “REPRIEVE is important because there are limited existing interventions to help prevent adverse cardiovascular outcomes in this population.”
The REPRIEVE study was primarily supported by NIAID and NHLBI, with additional funding from the NIH’s Office of AIDS Research, and was conducted by the AIDS Clinical Trials Group.
|
Sources 2/ https://www.ajmc.com/view/pitavastatin-calcium-linked-to-35-reduced-cvd-risk-in-people-with-hiv The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
