Health
Next-generation vaccine strategies to combat current and emerging SARS-CoV-2 variants
Announcement of new article publication of zoonotic disease journal. Vaccines are he one of the most effective medical countermeasures against infectious diseases. The emergence of the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spurred scientific strategies to combat this disease.
Since 2020, many vaccines based on different platforms have been developed in response to the pandemic, among which mRNA, adenoviral vector and subunit vaccines are clinically approved for human use. increase. These first-generation COVID-19 vaccines primarily target the viral spike (S) protein and aim to induce a potent virus. Neutralizing antibodyWith the emergence of SARS-CoV-2 variants, especially highly contagious Omicron strains, S-based vaccine strategies face a continuing challenge of potent immune escape by variants.
The nucleocapsid (N) protein of coronavirus is a viral protein that induces strong immunity. T cells immune and more conserved than the S protein among different SARS-CoV-2 variants. Inclusion of the N protein in the development of a COVID-19 vaccine has been reported. The authors of this article discuss COVID-19, current S protein-based vaccine strategies, the immunobiology of N protein in SARS-CoV-2 host immunity, and the next generation including N protein to combat current and emerging SARS. Consider and discuss vaccine strategies. -CoV-2 variant.
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Journal reference:
Bonam, SR & Hu, H., (2023) Next-generation vaccines against COVID-19 variants: beyond spike proteins. zoonotic disease. doi.org/10.15212/ZOONOSES-2023-0003.
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