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Frequent use of antibiotics, sugary diet, and urban living increase risk of childhood inflammatory bowel disease

Frequent use of antibiotics, sugary diet, and urban living increase risk of childhood inflammatory bowel disease

 


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Tucker N et al. Abstract 350: Antibiotics, urban settings, and western dietary patterns increase the risk of childhood inflammatory bowel disease: a meta-analysis. Presented at: Digestive Disease Week. May 5-9, 2023. Chicago (hybrid conferencing).

Disclosure:
Mr. Tucker has not reported any related financial disclosures.


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Chicago — a diet rich in sweet candies and drinks, exposure to antibiotics Early childhood and urban living are among the risk factors for developing childhood inflammatory bowel disease, according to Gastroenterology Week data.

“Recognizing the impact of pediatric-specific modifiable and nonmodifiable causative factors and considering these during clinical work-up may help children at high IBD risk who can be closely monitored with a lower threshold for suspicion of developing IBD.” can be useful in identifying the Nisha Tucker, be Helio, a practicing nutritionist and PhD candidate at the University of Newcastle School of Health Sciences and Westmead Children’s Hospital, Australia, said.

Diagram showing exposure risks for childhood IBD.

Data were obtained from Thacker N et al. Abstract 350: Antibiotics, Urban Environment, and Western Dietary Patterns Increase Risk of Childhood Inflammatory Bowel Disease: A Meta-Analysis. Presented at: Digestive Disease Week. May 5-9, 2023. Chicago (hybrid conferencing).

to understand Influence on diet and environmental factors Thacker et al., who work on pediatric IBD, conducted a systematic search to identify studies linking diet and environmental exposures prior to diagnosis of pediatric IBD. Of the 4,763 studies screened, researchers analyzed 36 observational studies involving 6,463,448 participants.

Results showed that the odds of being diagnosed with childhood IBD were higher in individuals exposed to antibiotics during childhood (OR = 3; was significantly higher in those individuals (OR). = 3.63; 95% CI, 2.59–5.08).

In addition, atopic disease was associated with higher socioeconomic status (OR = 3.43; 95% CI, 2.11-5.55), passive smoking (OR = 2.34, OR = 2.34; 95% CI, 1.51-3.64), lifestyle (OR = 1.7; 95% CI, 0.96-3), history of non-breastfeeding (OR = 2.49; 95% CI, 1.13-5.46). Eating too many sugary drinks and candy also increases the risk of childhood IBD (OR = 2.02; 95% CI, 1.06-3.85).

Conversely, if there are two or more siblings (OR = 0.69; 95% CI, 0.64–0.74) and if there is contact with pets or cattle (OR = 0.53; 95% CI, 0.39–0.73), children The researchers reported a significant reduction in the risk of IBD. .

“Clinicians should encourage healthy early breastfeeding practices, including breastfeeding, and evaluate other known risk and protective factors for families, especially for families presenting with nonmodifiable factors such as having a family history of IBD. ,” Tucker said.

“Referring high-risk families to medical institutions” A nutritionist to help introduce a healthy, whole food-based diet It can be beneficial. This may help minimize the combined effects of Western dietary patterns on genetic risk. ”

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