Health
Oral estrogen-only use for menopausal women poses higher risks than patches or vaginal creams, study finds
CNN
—
People taking estrogen-only tablets menopause A new study found that people using patches and creams were more likely to be diagnosed with high blood pressure. However, treating physicians menopause Estrogen-only tablets are rarely prescribed to high-risk patients, he said. overall benefits Limitations of hormone replacement therapy outweigh the risks for many patients.
hormone replacement therapy, Alternatively, HRT can be administered as estrogen alone, progesterone alone, or estrogen and progesterone to address menopausal symptoms such as hot flashes, chills, night sweats, sleep disturbances, mood changes, vaginal dryness, and pain during intercourse. increase. In most cases, progestin, a synthetic version of progesterone, is used for duplex formation.
A study found that menopausal women taking estrogen-only tablets were 14% more likely to be diagnosed with high blood pressure than those using estrogen-only patches. Those taking oral estrogen were 19% more likely to be diagnosed with high blood pressure than those using estrogen-only vaginal creams or suppositories.
“This is the largest study to include only women who took only estrogen as HRT and never took progestin,” said Sophia Ahmed, senior author of the study and professor of Medicine Cummings, University of Calgary, Canada. said Dr. .
When taken as a tablet, estrogen is primarily metabolized in the liver, where the hormone becomes inactive and is excreted from the body via urine and feces. When applied as a patch to the skin, estrogen enters the bloodstream and bypasses the liver, whereas vaginal creams and suppositories are absorbed locally.
Still, this is all estrogen, so why would taking it orally make a difference?
Dr. Stephanie Fabion, director of the Mayo Clinic Women’s Health Center, said physicians treating menopause “do not take oral estrogen because estrogen passes through the liver and increases blood clot proteins and triglycerides, causing a slight increase in blood pressure.” I don’t use it anymore,” he said. Researchers in Jacksonville, Fla., were not involved in the study.
“But we already knew this Research on women’s health initiatives, blood pressure was found to rise by 1-1.5 millimeters of mercury. It’s like your blood pressure goes from 128 to 129,” said Fabion, who is also the medical director. North American Menopause Association, A professional association that provides certification to menopause professionals.
“The North American Menopause Society recommends that women under the age of 60 who are symptomatic within the first 10 years of menopause should: The benefits still outweigh the risks” said Fabion. “Also, for women with risk factors, we try to minimize risk by using transdermal rather than oral administration to avoid first-pass metabolism through the liver.”
the study, published on monday The journal Hypertension examined the medical records of more than 112,000 Canadian women aged 45 and over who received estrogen-only hormone therapy for at least six months between 2008 and 2019. The majority of study participants used estrogen for more than that.than 3 years.
Routes of administration include oral, transdermal, vaginal and intramuscular. The route of administration was excluded from the study because few study participants used intramuscular estrogen.
Fifty-five percent of study participants used synthetic estradiol. Estradiol is the most potent and prevalent female hormone throughout a woman’s lifetime. Cleveland Clinic.
The other two are estetrol, which is produced only during pregnancy, and estrone, a weak estrogen that continues to be produced after menopause. Only 5% of those in the study used estrone as a method of hormone replacement.
Conjugated equine estrogens are one of the oldest forms of estrogen therapy and were used by 40% of study participants. 10+ estrogens In this version It is isolated naturally or synthetically from the urine of pregnant horses and has been marketed ever since. In the 1940s, it was sold under the brand name Premarin (PREgnant MARes’ urINe). There are many other brands on the market today.
The researchers then analyzed medical records to see which study participants had developed high blood pressure within two years. Not only are those taking oral estrogens at higher risk than those taking percutaneous or vaginal births, but those taking conjugated equine estrogens are more likely to be diagnosed with hypertension than those taking estradiol. The study found an 8% higher risk.
“We also found that the longer people took oral estrogen, the more likely they were to be diagnosed with hypertension or hypertension,” said lead study author Ahmed. Higher doses also come with greater risks, she noted.
Because medical records were used in the study, researchers could only analyze information collected by the attending physician, which introduced some serious limitations to the study, Ahmed said.
“We didn’t know if they were smokers, if they were sedentary or if they were very active, what their BMI[body mass index]was, and if they were obese,” Ahmed said. rice field. “All these factors play a role in determining the risk of developing hypertension.”
Samar El-Coudary, professor of epidemiology at the University of Pittsburgh School of Public Health, who was not involved in the study, said the lack of information on weight is particularly critical.
“BMI is the biggest risk factor for hypertension. The difference in blood pressure they found may simply be due to excess weight,” said Elle Coudary, lead author of the American Heart Association paper. 2020 guidelines About menopause and cardiovascular risk.
“We know that obesity can actually cause the ovaries to shut down in young women. In older women, adipose tissue produces more estrogen by converting testosterone to estrogen.” she said.
But the biggest problem with the study, she said, was that it didn’t compare pills, patches, or vaginal injections with age-matched women who didn’t take any estrogen.
“Since this study did not include a non-estrogen control group, we cannot conclude that oral estrogen use alone is associated with an increased risk of high blood pressure in women,” El-Coudary said. rice field. “I can’t say that.”
Larger randomized studies that “considered all the complexities of hormone therapy around this critical transition in a woman’s life cycle” are needed, Ahmed said. “At the end of the day, what’s best for someone going through menopause is an individual decision and should be an open conversation with your doctor and health care team.”
|
Sources 2/ https://www.cnn.com/2023/06/05/health/oral-estrogen-blood-pressure-wellness/index.html The mention sources can contact us to remove/changing this article |
What Are The Main Benefits Of Comparing Car Insurance Quotes Online
LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos
to request, modification Contact us at Here or [email protected]
 |
 |
 |
