Health
US moves to trivalent vaccine for next year's flu season
this article Published on our sister site Drug Topics.
Earlier this month, the FDA's Vaccines and Related Biological Products Advisory Committee recommended transitioning all influenza vaccines in the United States from quadrivalent to trivalent vaccines for the 2024-2025 influenza season.1
The trivalent vaccine formulation still includes influenza A(H1N1), A(H3N2), and B/Victoria lineage vaccine viruses, but influenza B/Yamagata virus has been omitted as it is no longer actively circulating. Masu.
“FDA is implementing an FDA-approved seasonal influenza vaccine to facilitate the timely availability of an approved, safe and effective trivalent seasonal influenza vaccine for the 2024-2025 U.S. influenza season.” “We are engaging and interacting with influenza vaccine manufacturers and providing them with scientific and regulatory advice.” FDA news release.2 “FDA anticipates there will be an adequate and diverse supply of trivalent seasonal influenza vaccines approved for the United States next season.”
Each year, scientists review and update the composition of the U.S. flu vaccine to target strains predicted to be most prevalent during the next flu season. Based on past reviews, this is not the first time a trivalent vaccine has been administered to patients seeking influenza vaccination.
From the 1978-1979 season to the 2012-2013 season, influenza vaccines in the United States contained three vaccine viruses. Influenza A(H1N1), A(h3N2), and B-lineage vaccine viruses from B/Yamagata or B/Victoria. system.1 The quadrivalent influenza vaccine first became available in the United States during the 2013-2014 influenza season and remains the standard composition through the current influenza season (2023-2024).1
Moving from quadrivalent to trivalent vaccines will increase current production capacity by 200 million doses, allowing more patients to receive influenza vaccinations.3 This expanded access could help reduce the significant health burden that influenza poses to the United States. This past influenza season was classified by the CDC as moderately severe for adults and highly severe for children.Four— as well as easing vaccine the scarcity and unequal distribution that developing countries often experience;3
Each year, this virus causes millions of infections, hundreds of thousands of hospitalizations, and billions of dollars lost in medical costs and missed work.3
Vaccines have long been considered the first-line defense against influenza, and have been recommended in the United States for more than 50 years for everyone over 6 months of age, with rare exceptions.1 These are clinically proven to reduce the severity of the virus and reduce the risk of developing potentially serious complications.
Some experts believe that public health measures such as lockdowns, travel restrictions and mask mandates to curb the spread of SARS-COV-2 during the coronavirus pandemic have inadvertently spread to Yamagata. They say it may have reduced the spread of B.3. Since March 2020, it has been detected to be actively circulating in global surveillance.1 It has been suggested that these measures may have completely stopped the cycle.
Changes in vaccine composition can cause confusion and misinformation, so effective communication, including through public health campaigns and doctor-patient discussions, is essential to promoting vaccine uptake.Five Healthcare providers and public health officials can help ensure patient safety by explaining the rationale behind the composition change and emphasizing the continued effectiveness of trivalent vaccines against influenza.
References
1. The United States plans to transition to trivalent influenza vaccines in 2024-2025. news release. CDC. March 8, 2024. Accessed March 13, 2024. https://www.cdc.gov/flu/spotlights/2023-2024/trivalent-vaccines-2024-2025.htm#:~:text=The%20Committee%20recommended%20that%20all,%2FVictoria-lineage%20vaccine% 20 viruses.
2. Use of trivalent influenza vaccines in the 2024-2025 U.S. influenza season. news release. F.D.A. March 5, 2024. Accessed March 13, 2024. https://www.fda.gov/vaccines-blood-biologics/lot-release/use-trivalent-influenza-vaccines-2024-2025-us-influenza-season
3. Vajo Z, Torzsa P. Extinction of the influenza B Yamagata strain during the COVID-19 pandemic – implications for vaccine composition. virus. 2022;14(8):1745. doi:10.3390/v14081745
4. White EB, O'Halloran A, Sundaresan D, et al. High Influenza Incidence and Severity in Children and Adolescents Under 18 – United States, 2022-23 Season. MMWR Morb Mortal Wkly Rep. 2023;72(41):1108-1114. doi:10.15585/mmwr.mm7241a2
5. How will Meara K. B/Yamagata's extinction impact global influenza vaccination strategies? News article. drug topic. February 13, 2024. Accessed March 13, 2024. https://www.drugtopics.com/view/how-will-the-extinction-of-b-yamagata-impact-global-flu-vaccination-strategies-
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