Health
2024 ACP Type 2 Diabetes Recommendations
reflects the growing evidence base supporting the safety and effectiveness of these classes in management. type 2 diabetes The American College of Physicians supports SGLT2 inhibitors and GLP-1 receptor agonists and opposes the use of DPP-4 inhibitors as second-line therapy to metformin in adults with type 2 diabetes and poor glycemic control. issued recommendations.
Carolyn J. Crandall, author It is important to verify that.” M.D., M.S., Internal Medicine, University of California, Los Angeles School of Medicine, Chair of the Guidelines Committee.
Released on the first day of ACP 2024 Society of Internal Medicine, the pair of recommendations reflects findings from systematic reviews, network meta-analyses, and cost-effectiveness analyzes evaluating the value of these treatments as monotherapy and in combination with metformin. Of note, this recommendation does not take into account the impact of each class on glycemic parameters.
Here are the recommendations from the ACP:
- Recommendation 1: Add an SGLT2 inhibitor or GLP-1 receptor agonist to metformin and modify lifestyle in adults with type 2 diabetes and poor glycemic control (strongly recommended; high-certainty evidence).
- SGLT2 inhibitors are used to reduce the risk of all-cause mortality, major cardiovascular events, progression of chronic kidney disease, and hospitalization for congestive heart failure.
- GLP-1 agonists are used to reduce the risk of all-cause mortality, major cardiovascular events, and stroke.
- Recommendation 2: Against adding DPP-4 inhibitors to metformin and modifying lifestyle in adults with type 2 diabetes and inadequate glycemic control to reduce morbidity and all-cause mortality (Strongly recommended; high-certainty evidence).
This year's Internal Medicine Conference attendees include Dr. Diana Isaacs, endocrine clinical pharmacist, Director of Diabetes Technology Education and Training, and Co-Director of Endocrine Diseases in Pregnancy at the Cleveland Clinic, and Diabetes Technology Program Director This is Natalie Bellini from DNP. Discussing his ACP's latest recommendations in the ACP 2024 Special Edition at the Center for Diabetes and Metabolic Care at University Hospitals. Diabetes Dialogue: Technology, Therapeutics, and Real-World Perspectives.
Disclosures related to Dr. Isaacs include Eli Lilly and Company, Novo Nordisk, Sanofi, Abbott Diabetes Care, Dexcom, Medtronic, and others. Disclosures related to Dr. Bellini include Abbott Diabetes Care, MannKind, Sanofi, and others.
References:
- Kaseem A, Obry AJ, Shamriyan T, Hicks LA, Harrod CS, Crandall CJ. New pharmacotherapies for adults with type 2 diabetes: American College of Physicians clinical guidelines. Annual report of internal medicine. Published online April 19, 2024. doi:10.7326/m23-2788
- American College of Physicians. The ACP issues clinical recommendations for new drug treatments for adults with type 2 diabetes. ACP issues clinical recommendations for new drug treatments for adults with type 2 diabetes. ACP Online. April 19, 2024. Accessed April 19, 2024. https://www.acponline.org/acp-newsroom/acp-issues-clinical-recommendations-for-newer-pharmacological-treatments-of-Adults-with-type-2.
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