Health
Multiple first-line therapies as part of the response to antimalarial drug resistance
overview
Effective malaria case management requires rapid access to diagnosis and antimalarial treatment to reduce morbidity and mortality. Artemisinin-based combination therapy (ACT) has been essential in malaria treatment since 2001, as it combines artemisinin, which rapidly reduces parasites, with partner drugs that ensure complete cure. However, resistance to antimalarial drugs threatens malaria control as the parasite can survive beyond standard doses.
Partial resistance to artemisinin, associated with Puchkerch 13 Recently, a mutation has emerged in several African countries that slows down the time it takes to eliminate the parasite. Artemisinin partial resistance does not lead to ACT failure if the partner drug is still effective. However, further increase in resistance to partner drugs may compromise the efficacy of ACT. To address this threat, WHO has launched a strategy to address antimicrobial resistance in Africa in 2022. This strategy aims to improve detection, enable timely response, and reduce the impact of drug resistance through evidence-based measures.
This strategy includes multiple measures, including multiple first-line therapies (MFTs), aimed at extending the treatment life of ACT. This implementation guide provides guidance for malaria programs by defining MFT, reviewing its impact on resistance, assessing implications for policy and practice, and identifying evidence gaps for future research.
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Sources 2/ https://www.who.int/publications/i/item/9789240103603 The mention sources can contact us to remove/changing this article |
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