Intestinal microbiology may mediate the relationship between sugar beverages and diabetes.

It is well known that consuming sugar -like drinks increase the risk of diabetes, but the mechanism behind this relationship is unknown. By the way, in a paper published by CELL PRESS JOURNAL on January 31st Cell metabolismResearchers have indicated that metabolites generated by intestinal microorganisms may play a role. Hispanic/Latin adult long -term cohort, researchers Intestinal microscopic porous An individual blood metabo product with a high intake of drinks for sugar. The changed metabolic profile found in sugar drinks was associated with the high risk of developing diabetes in the next decade. This is produced by intestinal microorganisms Micro -biome There is a possibility of mediation of sugar beverages and diabetes.

Our research suggests a potential mechanism where sugar -sweetened drinks explain why you are bad for your metabolism. Our survey results are observed, but we provide insights on potential diabetes and management strategies using intestinal microbias. ”

Qibin Qi, Senior, Albert Einstein School Epidemiology

Sugar sweet drinks are the main sources of sugar in 2017 and 2018, which are the main sources of sugar for adult diets, and adults in the United States consume 34.8 g of sugar on average from sweet drinks such as soda and sweet fruit juice. I did. Compared to the sugar on solid foods and sugar to the drink, “it may be easier to absorb and only sugar and water, so it has a very high energy density.” Says Qi.

Previous research in Europe and China shows that drinks that have been sugar change the composition of intestinal microorganisms, which affects the risk of the lord and the risk of diabetes. This is the first research to investigate whether or not. This is also the first study of the US -based Hispanic/Latin group. It is known to experience the rate of diabetes and consume a large amount of sugar.

The team is ongoing Hispanic Community Health Research/Latin American research (HCHS/SOL) data, large cohoat using more than 16,000 participants living in San Diego, Chicago, Miami, and Bronx. I used research data. In the first visit, the participants were asked to recall meals from the past 24 hours, and collected blood to characterize serum metabolites. Researchers have collected fecal samples and featured the participant's substrate, intestinal microorganism (n = 3,035), and using these data, sugar -processed and intestinal microbial composition, using these data. The relationship with serum metabolism has been identified.

They have discovered that high -sugar beverage intake, which is defined as two or more sugar beverages per day, is related to the abundant change of nine bacteria. It is known that four of these species are produced when bacteria are digested and have a positive effect on glucose metabolism. Generally, bacterial species that have a positive and positive intake of sugar beverages are correlated with worse metabolic characteristics. Interestingly, these bacteria were not related to sugar consumed from non -childcare sources.

Researchers also have the relevance of sugar beverages consumption and 56 serum metabolites, which are generated by sugar mass microbias or are derivatives of an intestinal bacterial generated metabolites. I found it. These sugar -related metabolic products have a higher level of hungry blood glucose and insulin, have a higher ratio of BMI, waist and hips, and has a low level of high -density lipotent protein cholesterol (“good” cholesterol). It was associated with bad metabolic characteristics. In particular, individuals with high levels of these metabolites were more likely to develop diabetes over the first ten years after their first visit.

“I know that some microbias -related metabolites are related to the risk of diabetes,” Qi says. “In other words, these metabolites may predict future diabetes.”

Since the intestinal microbiomut sample was collected only from the participant's subset, researchers had insufficient sample size to determine whether intestinal microorganisms were directly related to the risk of diabetes. But this is what we plan to study further.

“In the future, I would like to test whether bacteria and metabolites can intervene between drinks that have joined sugar and the risk of diabetes, at least.”

The team is planning to verify the survey results in other groups, expand the analysis, and investigate whether microorganisms are involved in other chronic health issues related to sugar consumption, such as cardiovascular diseases. I am doing it.

This study was supported by National Diabetes and Diabetic Disease and Kidney Disease Research Institute, National Heart, Lung, Blood Research Institute, the National Institute of Health and Health, the New York Diabetes Regional Translation Research Division, and the National Institute of Environment. I did it. Health science and JLH Foundation.